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Detection of recurrent nasopharyngeal carcinomas with positron emission tomography using 18-fluoro-2-deoxyglucose in patients with indeterminate magnetic resonance imaging findings after radiotherapy

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Abstract

Purpose. The aim of this study was to evaluate the effectiveness of positron emission tomography (PET) using 18-fluoro-2-deoxyglucose (FDG) to detect recurrent nasopharyngeal carcinomas (NPC) when magnetic resonance imaging (MRI) findings are indeterminate.

Patients and methods. After radiotherapy, 28 NPC patients with indeterminate MRI findings were included. MRI, FDG-PET, and biopsy were performed at least 4 months after radiotherapy and within 1 week. The final results were based on histopathologic findings and a clinical follow-up of at least 6 months.

Results. For detecting recurrent NPC in indeterminate MRI findings, the sensitivity, specificity and accuracy of FDG-PET were 100.0%, 92.9% and 96.4%, respectively.

Conclusions. Based on these results, we can recommend FDG-PET for detecting recurrent NPC when MRI findings are indeterminate.

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Authors and Affiliations

  1. Department of Otolaryngology, China Medical College Hospital, Taichung, Taiwan, , , , ,

    M. Tsai

  2. Department of Nuclear Medicine, Far Eastern Memorial Hospital and Institute of Biomedical Engineering, College of Electrical Engineering, Taipei, Taiwan, , , , ,

    Y. Shiau

  3. Department of Nuclear Medicine, China Medical College Hospital, No. 2, Yuh-Der Road, Taichung 404, Taiwan, , , , ,

    C. Kao

  4. Department of Nuclear Medicine and PET Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan, , , , ,

    Y. Shen

  5. Department of Family Medicine, China Medical College Hospital, Taichung, Taiwan, , , , ,

    C. Lin

  6. Department of Medical Research, China Medical College Hospital, Taichung, Taiwan, , , , ,

    C. Lee

Authors
  1. M. Tsai
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  2. Y. Shiau
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  3. C. Kao
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  4. Y. Shen
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  5. C. Lin
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  6. C. Lee
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Tsai, .M., Shiau, .Y., Kao, .C. et al. Detection of recurrent nasopharyngeal carcinomas with positron emission tomography using 18-fluoro-2-deoxyglucose in patients with indeterminate magnetic resonance imaging findings after radiotherapy. J Cancer Res Clin Oncol 128, 279–282 (2002). https://doi.org/10.1007/s00432-002-0341-6

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  • DOI: https://doi.org/10.1007/s00432-002-0341-6

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