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Lower genital tract metastases at time of first diagnosis of mammary invasive lobular carcinoma

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Abstract

Introduction

Although breast cancer is a major health problem worldwide, metastatic disease to the lower genital tract remains to be a rare event.

Case report

A 64-year old woman was admitted to our hospital due to newly diagnosed ascites and peripheral edema. A computer tomography had shown peritoneal carcinosis but no clear evidence of an intraabdominal mass. CA 12-5 levels were elevated. Physical examination of the breast did not show any abnormal findings, except for the fact that the patient was post bilateral breast augmentation in 1999. The peritoneal carcinosis was thought to originate from the ovaries or the endometrium and therefore the patient underwent a laparotomy with hysterectomy, bilateral salpingoovariectomy and omentectomy. Histological findings revealed a low differentiated adenocarcinoma, most likely originating from primary breast cancer. A bilateral mammography was suspicious of a tumour in the left breast which was confirmed in a second surgery. Histology showed a moderately differentiated invasive-lobular breast cancer.

Conclusion

To our knowledge, this is the first report about metastasis to the lower genital tract on initial presentation of an invasive-lobular carcinoma. In the differential diagnosis of peritoneal carcinosis, metastases of an invasive-lobular carcinoma should be considered.

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References

  1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ (2009) Cancer statistics. CA Cancer J Clin 59(4):225–249. doi:10.3322/caac.20006

    Article  PubMed  Google Scholar 

  2. Famoriyo A, Sawant S, Banfield PJ (2004) Abnormal uterine bleeding as a presentation of metastatic breast disease in a patient with advanced breast cancer on tamoxifen therapy. Arch Gynecol Obstet 270(3):192–193. doi:10.1007/s00404-003-0500-2

    Article  PubMed  Google Scholar 

  3. Piura B, Yanai-Inbar I, Rabinovich A, Zalmanov S, Goldstein J (1999) Abnormal uterine bleeding as a presenting sign of metastases to the uterine corpus, cervix and vagina in a breast cancer patient on tamoxifen therapy. Eur J Obstet Gynecol Reprod Biol 83(1):57–61. doi:10.1016/S0301-2115(98)00268-1

    Article  PubMed  CAS  Google Scholar 

  4. Karvouni E, Papakonstantinou K, Dimopoulou C, Kairi-Vassilatou E, Hasiakos D, Gennatas CG, Kondi-Paphiti A (2009) Abnormal uterine bleeding as a presentation of metastatic breast disease in a patient with advanced breast cancer. Arch Gynecol Obstet 279(2):199–201. doi:10.1007/s00404-008-0665-9

    Article  PubMed  Google Scholar 

  5. Silverberg SG, Kurman RJ (1992) Atlas of Tumor Pathology: Tumors of the Uterine Corpus and Gestational Trophoblastic Disease, 3rd edn. Washington, 7 Armed Forces Institute of Pathology

  6. Mazur MT, Hsueh S, Gersell DJ (1984) Metastases to the female genital tract. Analysis of 325 cases. Cancer 53(9):1978–1984

    Article  PubMed  CAS  Google Scholar 

  7. Erkanli S, Kayaselcuk F, Kuscu E, Bolat F, Sakalli H, Haberal A (2006) Lobular carcinoma of the breast metastatic to the uterus in a patient under adjuvant anastrozole therapy. Breast 15(4):558–561. doi:10.1016/j.breast.2005.10.008

    Article  PubMed  Google Scholar 

  8. Ustaalioglu BB, Bilici A, Seker M, Salman T, Gumus M, Barisik NO, Salepci T, Yaylaci M (2009) Metastasis of lobular breast carcinoma to the uterus in a patient under anastrozole therapy. Onkologie 32(7):424–426. doi:10.1159/000218367

    Article  PubMed  Google Scholar 

  9. Scopa CD, Aletra C, Lifschitz-Mercer B, Czernobilsky B (2005) Metastases of breast carcinoma to the uterus. Report of two cases, one harboring a primary endometrioid carcinoma, with review of the literature. Gynecol Oncol 96(2):543–547. doi:10.1016/j.ygyno.2004.09.064

    Article  PubMed  Google Scholar 

  10. Kemp B, Schröder W, Hermann A, Biesterfeld S, Rath W (1997) Uterine metastasis of invasive lobular breast carcinoma. Case report and review of the literature with reference to differential diagnostic problems and clinical consequences. Zentralbl Gynakol 119(10):500–502

    PubMed  CAS  Google Scholar 

  11. Rau AR, Saldanha P, Raghuveer CV (2003) Metastatic lobular mammary carcinoma diagnosed in cervicovaginal smears: a case report. Diagn Cytopathol 29(5):300–302. doi:10.1002/dc.10385

    Article  PubMed  Google Scholar 

  12. Li CI, Uribe DJ, Daling JR (2005) Clinical characteristics of different histologic types of breast cancer. Br J Cancer 93(9):1046–1052. doi:10.1038/sj.bjc.6602787

    Article  PubMed  CAS  Google Scholar 

  13. Dian D, Herold H, Mylonas I, Scholz C, Janni W, Sommer H, Friese K (2009) Survival analysis between patients with invasive ductal and invasive lobular breast cancer. Arch Gynecol Obstet 279(1):23–28. doi:10.1007/s00404-008-0662-z

    Article  PubMed  Google Scholar 

  14. Bogliolo S, Morotti M, Valenzano Menada M, Fulcheri E, Musizzano Y, Casabona F (2010) Breast cancer with synchronous massive metastasis in the uterine cervix: a case report and review of the literature. Arch Gynecol Obstet 281(4):769–773. doi:10.1007/s00404-009-1264-0

    Article  PubMed  Google Scholar 

  15. Cannistra SA (2004) Cancer of the ovary. N Engl J Med 351(24):2519–2529

    Article  PubMed  CAS  Google Scholar 

  16. Handel N (2007) The effect of silicone implants on the diagnosis, prognosis, and treatment of breast cancer. Plast Reconstr Surg 120(7 Suppl 1):81S–93S. doi:10.1097/01.prs.0000286578.94102.2b

    Article  PubMed  CAS  Google Scholar 

  17. Deapen D (2007) Breast implants and breast cancer: a review of incidence, detection, mortality, and survival. Plast Reconstr Surg 120(7 Suppl 1):70S–80S. doi:10.1097/01.prs.0000286577.70026.5d

    Article  PubMed  CAS  Google Scholar 

  18. Kang BJ, Kim SH et al (2010) The clinical and imaging characteristics of breast cancers in patients with interstitial mammoplasty. Arch Gynecol Obstet 281(6):1029–1035. doi:10.1007/s00404-009-1276-9

    Article  PubMed  Google Scholar 

  19. Tarone RE, Lipworth L, Young VL, Mc Laughlin JK (2004) Breast reduction surgery and breast cancer risk: does reduction mammaplasty have a role in primary prevention strategies for women at high risk of breast cancer? Plast Reconstr Surg 113(7):2104–2110

    Google Scholar 

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Correspondence to Ioannis Mylonas.

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Engelstaedter, V., Mylonas, I. Lower genital tract metastases at time of first diagnosis of mammary invasive lobular carcinoma. Arch Gynecol Obstet 283 (Suppl 1), 93–95 (2011). https://doi.org/10.1007/s00404-011-1843-8

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