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Head and neck squamous cell carcinoma: usefulness of diffusion-weighted MR imaging in the prediction of a neoadjuvant therapeutic effect

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Abstract

The purpose of our study was to evaluate the usefulness of diffusion-weighted imaging in predicting the responses to neoadjuvant therapy for head and neck squamous cell carcinomas. Diffusion-weighted, T2-weighted, and gadolinium-enhanced T1-weighted images were obtained from 28 patients with untreated head and neck squamous cell carcinomas with histological proof. A blinded radiologist evaluated the quantitative and qualitative signal intensities and apparent diffusion coefficients (ADCs) in the lesions on each sequence. All patients were treated by neoadjuvant therapies, and the post-therapeutic tumor regression rate was determined. Both the quantitative and qualitative signal intensities on diffusion-weighted images showed positive correlations (r = 0.367 and 0.412, p < .05), and the ADCs showed a weak, inversed correlation (r = −0.384, p < .05) with the tumor regression rates. Diffusion-weighted imaging including an assessment by ADCs may be able to predict tumor response to neoadjuvant therapy for head and neck squamous cell carcinomas.

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Authors and Affiliations

  1. Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu, 501–1194, Japan

    Hiroki Kato, Masayuki Kanematsu, Osamu Tanaka & Hiroaki Hoshi

  2. High-level Imaging Diagnosis Center, Gifu University Hospital, 1-1 Yanagido, Gifu, 501–1194, Japan

    Masayuki Kanematsu

  3. Department of Otolaryngology, Gifu University School of Medicine, Gifu, Japan

    Keisuke Mizuta & Mitsuhiro Aoki

  4. Department of Oral and Maxillofacial Sciences, Gifu University Graduate School of Medicine, Gifu, Japan

    Toshiyuki Shibata & Tomomi Yamashita

  5. Department of Pathology, Gifu University School of Medicine, Gifu, Japan

    Yoshinobu Hirose

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  1. Hiroki Kato
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  2. Masayuki Kanematsu
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  3. Osamu Tanaka
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  4. Keisuke Mizuta
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  6. Toshiyuki Shibata
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  8. Yoshinobu Hirose
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  9. Hiroaki Hoshi
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Correspondence to Hiroki Kato.

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Kato, H., Kanematsu, M., Tanaka, O. et al. Head and neck squamous cell carcinoma: usefulness of diffusion-weighted MR imaging in the prediction of a neoadjuvant therapeutic effect. Eur Radiol 19, 103–109 (2009). https://doi.org/10.1007/s00330-008-1108-5

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  • DOI: https://doi.org/10.1007/s00330-008-1108-5

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