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18F-fluorodeoxyglucose positron emission tomography in patients with recurrent ovarian cancer: in comparison with vascularity, Ki-67, p53, and histologic grade

  • Nuclear Medicine
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Abstract

The aim of this study was to assess the correlation between 18F-fluorodeoxyglucose positron emission tomography (FDG PET) positivity of tumor recurrence and vascularity, Ki-67, p53, and histologic grade in patients with ovarian cancer. Nineteen patients with recurrent ovarian cancer underwent FDG PET before second-look surgery. Archival paraffin-embedded tissue materials were used to assess histologic grade including architectural pattern, mitotic activity, and nuclear pleomorphism; intratumor microvessel density (MVD); Ki-67; and p53. Univariate analysis was used to evaluate the correlation between FDG PET positivity and each biomarker. Stepwise logistic regression analysis was used to determine the best parameter to explain FDG PET positivity. MVD revealed significant positive correlation with FDG PET positivity (p=0.0341). There was no significant correlation between FDG PET positivity and Ki-67 or p53 (p=0.4040, p=0.6027). Mitotic activity yielded statistically significant positive correlations with FDG PET positivity (p=0.0448) although histologic grade revealed no positive correlation (p=1). Stepwise logistic regression analysis revealed MVD to be the strongest parameter for FDG PET positivity (OR=0.696, 95% CI 0.487–0.993, p=0.0458). In conclusion, FDG PET positivity revealed positive correlation with MVD and mitotic activity. MVD was the strongest parameter in predicting positive tumor recurrence on FDG PET.

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Acknowledgement

The authors would like to express their appreciation to Dr. Gi Jeong Cheon and Jung Mi Park for their help in reviewing the FDG PET images.

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Authors and Affiliations

  1. Department of Radiology, Kangnam St. Mary’s Hospital, The Catholic University of Korea, Seocho-go, Banpo-dong, 137-701, Seoul, South Korea

    Song-Mee Cho & Jae Young Byun

  2. Department of Biostatics, Kangnam St. Mary’s Hospital, The Catholic University of Korea, Seocho-go, Banpo-dong, 137-701, Seoul, South Korea

    Yong Gyu Park

  3. Department of Gynecology, Kangnam St. Mary’s Hospital, The Catholic University of Korea, Seocho-go, Banpo-dong, 137-701, Seoul, South Korea

    Joon Mo Lee

  4. Department of Pathology, Kangnam St. Mary’s Hospital, The Catholic University of Korea, Seocho-go, Banpo-dong, 137-701, Seoul, South Korea

    Kyo-Young Lee & Gyeong-Sin Park

  5. Department of Radiology, St. Mary’s Hospital, The Catholic University of Korea, Yeongdeungpo-gu, Yeouido-dong 62, 150-713, Seoul, South Korea

    Jae Mun Lee

  6. Department of Radiology, St. Paul’s Hospital, The Catholic University of Korea, Dongdaemun-gu, Jeonnong-dong 620-56, 130-709, Seoul, South Korea

    Hyeon-Sook Kim, Bae Young Lee, Kang-Hoon Lee & Kyung-Sup Song

  7. Department of Pathology, St. Mary’s Hospital, The Catholic University of Korea, Yeongdeungpo-gu, Yeouido-dong 62, 150-713, Seoul, South Korea

    Gyeong-Sin Park

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  1. Song-Mee Cho
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  2. Yong Gyu Park
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  5. Jae Mun Lee
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  8. Hyeon-Sook Kim
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  9. Bae Young Lee
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Correspondence to Gyeong-Sin Park.

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Cho, SM., Park, Y.G., Lee, J.M. et al. 18F-fluorodeoxyglucose positron emission tomography in patients with recurrent ovarian cancer: in comparison with vascularity, Ki-67, p53, and histologic grade. Eur Radiol 17, 409–417 (2007). https://doi.org/10.1007/s00330-006-0326-y

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  • DOI: https://doi.org/10.1007/s00330-006-0326-y

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