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68Ga-PSMA PET/MR with multimodality image analysis for primary prostate cancer

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Abstract

Current imaging procedures for prostate cancer including positron emission tomography (PET) exhibit considerable limitations and are not always able to meet the diagnostic needs. Recently, a 68Gallium-labeled ligand of the prostate-specific membrane antigen (68Ga-PSMA) has been introduced in PET-imaging of prostate cancer with first promising results. Due to relatively exclusive expression of PSMA in prostatic tissue as well as increased expression in prostate cancer, 68 Ga-PSMA was reported to exhibit a favorable lesion to background ratio. Together with the novel development of combined PET/MRI, the combination of excellent morphological detail, multiparametric functional information, and molecular PET data might lead to a significant improvement in detection of prostate cancer. We present an exemplarily case of primary staging using multiparametric 68Ga-PSMA PET/MR by combining molecular and structural information.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany

    Matthias Eiber, Stephan G. Nekolla & Markus Schwaiger

  2. Department of Urology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany

    Tobias Maurer

  3. Department of Pathology, Klinikum rechts der Isar, Technische Universität München, Ismaninger Str. 22, 81675, Munich, Germany

    Gregor Weirich

  4. Pharmaceutical Radiochemistry, Technische Universität München, Garching, Germany

    Hans-Jürgen Wester

Authors
  1. Matthias Eiber
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  2. Stephan G. Nekolla
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  3. Tobias Maurer
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  4. Gregor Weirich
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  5. Hans-Jürgen Wester
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  6. Markus Schwaiger
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Correspondence to Matthias Eiber.

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Eiber, M., Nekolla, S.G., Maurer, T. et al. 68Ga-PSMA PET/MR with multimodality image analysis for primary prostate cancer. Abdom Imaging 40, 1769–1771 (2015). https://doi.org/10.1007/s00261-014-0301-z

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  • DOI: https://doi.org/10.1007/s00261-014-0301-z

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