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Somatostatin receptor-mediated imaging and therapy: basic science, current knowledge, limitations and future perspectives

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Abstract.

In vivo somatostatin receptor-mediated scintigraphy has proven to be a valuable method for the visualisation of neuroendocrine tumours and their metastases. A new application is the use of radiolabelled analogues for somatostatin receptor-mediated therapy. This paper presents a review on the basic science, historical background and current knowledge of somatostatin receptor subtypes and their expression in neuroendocrine tumours. New somatostatin analogues, new chelators, "new" radionuclides and combinations thereof are also discussed. Due attention is given to limitations and future perspectives of somatostatin receptor-mediated imaging and therapy.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Erasmus Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands

    Wout A. Breeman, Marion de Jong, Dik J. Kwekkeboom, Roelf Valkema, Willem H. Bakker, Peter P. Kooij & Eric P. Krenning

  2. Department of Internal Medicine, Erasmus Medical Centre Rotterdam, 3015 GD Rotterdam, The Netherlands

    Theo J. Visser

Authors
  1. Wout A. Breeman
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  2. Marion de Jong
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  3. Dik J. Kwekkeboom
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  4. Roelf Valkema
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  5. Willem H. Bakker
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  6. Peter P. Kooij
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  7. Theo J. Visser
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  8. Eric P. Krenning
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Breeman, W.A., de Jong, M., Kwekkeboom, D.J. et al. Somatostatin receptor-mediated imaging and therapy: basic science, current knowledge, limitations and future perspectives. Eur J Nucl Med 28, 1421–1429 (2001). https://doi.org/10.1007/s002590100502

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  • DOI: https://doi.org/10.1007/s002590100502

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