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Carbon-11 acetate as a tracer of myocardial oxygen consumption

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European Journal of Nuclear Medicine Aims and scope Submit manuscript

Abstract.

Estimation of myocardial oxygen consumption (MVO2) and myocardial blood flow (MBF) is important for the understanding of various (patho)physiological mechanisms and diseases. Clearance rates of carbon-11 labelled acetate, determined with positron emission tomography, allow estimation of MVO2 on a segmental level and non-invasively. In addition, MBF can be determined from uptake rates. In this review, the background to estimation of MVO2 and MBF is discussed, as well as the currently available literature that has used 11C-acetate to estimate MVO2 and MBF.

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Authors and Affiliations

  1. Department of Cardiology, University Hospital VU, P.O. Box 7057, 1007 MB Amsterdam, The Netherlands, The Netherlands

    Lucas J. Klein, Frans C. Visser, Paul Knaapen, Job H. Peters & Cees A. Visser

  2. Clinical PET Centre, University Hospital VU, Amsterdam, The Netherlands, The Netherlands

    Gerrit J.J. Teule & Adriaan A. Lammertsma

Authors
  1. Lucas J. Klein
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  2. Frans C. Visser
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  3. Paul Knaapen
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  4. Job H. Peters
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  5. Gerrit J.J. Teule
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  6. Cees A. Visser
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  7. Adriaan A. Lammertsma
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Klein, L., Visser, F., Knaapen, P. et al. Carbon-11 acetate as a tracer of myocardial oxygen consumption. Eur J Nucl Med 28, 651–668 (2001). https://doi.org/10.1007/s002590000472

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  • DOI: https://doi.org/10.1007/s002590000472

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