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Comparison between stress myocardial perfusion SPECT recorded with cadmium-zinc-telluride and Anger cameras in various study protocols

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Abstract

Purpose

The results of stress myocardial perfusion SPECT could be enhanced by new cadmium-zinc-telluride (CZT) cameras, although differences compared to the results with conventional Anger cameras remain poorly known for most study protocols. This study was aimed at comparing the results of CZT and Anger SPECT according to various study protocols while taking into account the influence of obesity.

Methods

The study population, which was from three different institutions equipped with identical CZT cameras, comprised 276 patients referred for study using protocols involving 201Tl (n = 120) or 99mTc-sestamibi injected at low dose at stress (99mTc-Low; stress/rest 1-day protocol; n = 110) or at high dose at stress (99mTc-High; rest/stress 1-day or 2-day protocol; n = 46). Each Anger SPECT scan was followed by a high-speed CZT SPECT scan (2 to 4 min).

Results

Agreement rates between CZT and Anger SPECT were good irrespective of the study protocol (for abnormal SPECT, 201Tl 92 %, 99mTc-Low 86 %, 99mTc-High 98 %), although quality scores were much higher for CZT SPECT with all study protocols. Overall correlations were high for the extent of myocardial infarction (r = 0.80) and a little lower for ischaemic areas (r = 0.72), the latter being larger on Anger SPECT (p < 0.001). This larger extent was mainly observed in 50 obese patients who were in the 201Tl or 99mTc-Low group and in whom stress myocardial counts were particularly low with Anger SPECT (228 ± 101 kcounts) and dramatically enhanced with CZT SPECT (+279 ± 251 %).

Conclusion

Concordance between the results of CZT and Anger SPECT is good regardless of study protocol and especially when excluding obese patients who have low-count Anger SPECT and for whom myocardial counts are dramatically enhanced on CZT SPECT.

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Acknowledgments

The authors thank: Henri Boutley for his help in image analysis, Pierre Pothier for critical review of the manuscript and Nancy University Hospital for financial and organizational support.

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Authors and Affiliations

  1. Department of Nuclear Medicine, CHU-Nancy, Nancy, 54000, France

    Antoine Verger, Wassila Djaballah, Grégoire Koehl, Laetitia Imbert, Véronique Roch, Gilles Karcher & Pierre-Yves Marie

  2. INSERM U947, Nancy, 54000, France

    Antoine Verger, Wassila Djaballah, Sylvain Poussier & Gilles Karcher

  3. Nancyclotep Experimental Imaging Platform, Nancy, 54000, France

    Antoine Verger, Grégoire Koehl, Laetitia Imbert, Sylvain Poussier, Véronique Roch, Gilles Karcher & Pierre-Yves Marie

  4. Clinique Pasteur, Toulouse, 31000, France

    Nicolas Fourquet

  5. Department of Nuclear Medicine, AP-HP, Hôpital Bichat, Paris, 75018, France

    François Rouzet & Dominique Le Guludec

  6. INSERM U 773 Inserm and Denis Diderot University, Paris, 75018, France

    François Rouzet & Dominique Le Guludec

  7. Department of Radiotherapy, Centre Alexis Vautrin, Vandoeuvre, 54500, France

    Laetitia Imbert

  8. Centre d’Investigation Clinique CIC-P 9501, INSERM, Nancy, 54000, France

    Renaud Fay

  9. INSERM U961, Nancy, 54000, France

    Pierre-Yves Marie

  10. Médecine Nucléaire, Hôpital de Brabois, CHU-Nancy, Allée du Morvan, 54500, Vandoeuvre-les-Nancy, France

    Pierre-Yves Marie

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  1. Antoine Verger
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  2. Wassila Djaballah
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  4. François Rouzet
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  7. Sylvain Poussier
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  12. Pierre-Yves Marie
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Correspondence to Pierre-Yves Marie.

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Verger, A., Djaballah, W., Fourquet, N. et al. Comparison between stress myocardial perfusion SPECT recorded with cadmium-zinc-telluride and Anger cameras in various study protocols. Eur J Nucl Med Mol Imaging 40, 331–340 (2013). https://doi.org/10.1007/s00259-012-2292-8

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  • DOI: https://doi.org/10.1007/s00259-012-2292-8

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