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Stress-induced myocardial ischemia is associated with early post-stress left ventricular mechanical dyssynchrony as assessed by phase analysis of 201Tl gated SPECT myocardial perfusion imaging

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

In 201Tl SPECT myocardial perfusion imaging (MPI) data are acquired shortly after the stress injection to assess early post-stress left ventricle (LV) function. The purpose of this study was to use 201Tl SPECT MPI to investigate whether stress-induced myocardial ischemia is associated with LV mechanical dyssynchrony.

Methods

Enrolled in the study were 75 patients who were referred for dipyridamole stress and rest 201Tl gated SPECT MPI. The early post-stress scan was started 5 min after injection, and followed by the rest scan 4 h later. The patients were divided into three groups: ischemia group (N = 25, summed stress score, SSS, ≥5, summed rest score, SRS, <5), infarct group (N = 16, SSS ≥5, SRS ≥5) and normal group (N = 34, SSS <5, SRS <5). LV dyssynchrony parameters were calculated by phase analysis, and compared between the stress and rest images.

Results

In the ischemia group, LV dyssynchrony was significantly larger during stress than during rest. On the contrary, LV dyssynchrony during stress was significantly smaller than during rest in the normal and infarct groups. LV dyssynchrony during rest was significantly larger in the infarct group than in the normal and ischemia groups. There were no significant differences in LV dyssynchrony during rest between the normal and ischemia groups.

Conclusion

Stress-induced myocardial ischemia caused dyssynchronous contraction in the ischemic region, leading to a deterioration in LV synchrony. Normal myocardium had more synchronous contraction during stress. The different dyssynchrony pattern between ischemic and normal myocardium early post-stress may aid the diagnosis of coronary artery disease using 201Tl gated SPECT MPI.

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Acknowledgments

This study was supported in part by a research grant from Show Chwan Memorial Hospital (RD100003) and an NIH grant (1R01HL094438, PI: Ji Chen, PhD).

Conflicts of interest

Dr. Ji Chen receives royalties from the sale of Emory SyncTool. The terms of this arrangement have been reviewed and approved by Emory University in accordance with its conflict-of-interest practice.

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Authors and Affiliations

  1. Department of Cardiology, Show Chwan Memorial Hospital, Changhua, Taiwan

    Chien-Cheng Chen & Thau-Yun Shen

  2. Department of Nuclear Medicine, Changhua Christian Hospital, Changhua, Taiwan

    Ming-Che Chang

  3. Department of Nuclear Medicine, Chang Bing Show Chwan Memorial Hospital, 6 Lukon Road, Lukong Town, Changhua, 505, Taiwan

    Guang-Uei Hung & Wan-Chen Chen

  4. Department of Biomedical Imaging and Radiological Science, China Medical University, Taichung, Taiwan

    Guang-Uei Hung & Chia-Hung Kao

  5. Department of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, GA, USA

    Ji Chen

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  1. Chien-Cheng Chen
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  2. Thau-Yun Shen
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  3. Ming-Che Chang
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  4. Guang-Uei Hung
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  5. Wan-Chen Chen
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  7. Ji Chen
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Correspondence to Guang-Uei Hung.

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Chen, CC., Shen, TY., Chang, MC. et al. Stress-induced myocardial ischemia is associated with early post-stress left ventricular mechanical dyssynchrony as assessed by phase analysis of 201Tl gated SPECT myocardial perfusion imaging. Eur J Nucl Med Mol Imaging 39, 1904–1909 (2012). https://doi.org/10.1007/s00259-012-2208-7

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  • DOI: https://doi.org/10.1007/s00259-012-2208-7

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