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Prognostic significance of SUVmax (maximum standardized uptake value) measured by [18F]FDG PET/CT in endometrial cancer

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Abstract

Purpose

To determine if the preoperative maximum standardized uptake value (SUVmax) measured by [18F]FDG PET/CT has prognostic value in patients with endometrial cancer.

Methods

A total of 57 patients with FIGO stage I–IV endometrial cancer underwent FDG PET/CT imaging before radical surgery. SUVmax of the primary tumour was compared with histological prognostic factors, and the relationship between SUVmax and recurrence was examined.

Results

The median duration of follow-up was 33.1 months (range 4 to 68 months). SUVmax was significantly higher in patients with a higher FIGO stage (p = 0.0015), higher tumour histological grade (p < 0.0001), myometrial invasion (p = 0.0020), larger tumour size (p = 0.0056) and lymph node metastasis (p = 0.027). Univariate analysis showed that SUVmax (uncategorized value), FIGO stage, tumour histological grade, lymph node metastasis and lymphovascular space invasion were significantly associated with recurrence. However, multivariate analysis showed that only SUVmax (p = 0.045, hazard ratio 1.11, 95% CI 1.0028–1.231) was significantly associated with recurrence. Based on ROC curve analysis and log-rank tests, patients with a high a SUVmax (≥12.7) had a significantly lower disease-free survival rate than those with a low SUVmax (<12.7; p = 0.00042).

Conclusion

Preoperative FDG uptake by the primary tumour is significantly associated with recurrence in patients with endometrial cancer.

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Acknowledgments

We thank Hiroyoshi Okajima, Keita Miyamoto, Eiji Takeda, and Kazuhiro Kubo for their excellent technical assistance and generous support.

Conflicts of interest

None.

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Authors and Affiliations

  1. Department of Radiology, Kobe University Graduate school of Medicine, 7-5-2 Kusunoki-cho, Chuo-ku, Kobe, 650-0017, Japan

    Kazuhiro Kitajima & Kazuro Sugimura

  2. Department of Obstetrics and Gynecology, Kobe City Medical Center General Hospital, Kobe, Japan

    Masato Kita

  3. Department of PET Diagnosis, Institute of Biomedical Research and Innovation, Kobe, Japan

    Kayo Suzuki

  4. Molecular Imaging, Institute of Biomedical Research and Innovation, Kobe, Japan

    Michio Senda

  5. Department of Diagnostic Imaging and Nuclear Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan

    Yuji Nakamoto

Authors
  1. Kazuhiro Kitajima
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  2. Masato Kita
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  3. Kayo Suzuki
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  4. Michio Senda
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  5. Yuji Nakamoto
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  6. Kazuro Sugimura
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Corresponding author

Correspondence to Kazuhiro Kitajima.

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Kitajima, K., Kita, M., Suzuki, K. et al. Prognostic significance of SUVmax (maximum standardized uptake value) measured by [18F]FDG PET/CT in endometrial cancer. Eur J Nucl Med Mol Imaging 39, 840–845 (2012). https://doi.org/10.1007/s00259-011-2057-9

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  • DOI: https://doi.org/10.1007/s00259-011-2057-9

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