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Gallium-labelled peptides for imaging of inflammation

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Abstract

Inflammation plays a major role in the development of many diseases. This review article summarizes recent research in the field of in vivo imaging of inflammation. Novel methodologies using PET with 68Ga peptides targeting, for example, vascular adhesion protein 1 are discussed.

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Acknowledgments

We thank Anu Autio, Petteri Lankinen, Tatu Mäkinen, Tiina Saanijoki, Johanna Silvola (née Haukkala), and Tiina Ujula for providing data and figures. The PET studies reviewed involving VAP-1-targeting tracers and 68Ga-DOTA-RGD peptide were conducted at the Finnish Centre of Excellence in Molecular Imaging in Cardiovascular and Metabolic Research supported by the Academy of Finland, the University of Turku, the Turku University Hospital and the Åbo Akademi University.

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Authors and Affiliations

  1. Turku PET Centre, University of Turku and Turku University Hospital, Kiinamyllynkatu 4-8, FI-20521, Turku, Finland

    Anne Roivainen

  2. Turku Center for Disease Modeling, University of Turku, 20014, Turku, Finland

    Anne Roivainen

  3. MediCity Research Laboratory, University of Turku, 20520 , Turku, Finland

    Sirpa Jalkanen

  4. Department of Medical Microbiology and Immunology, University of Turku, 20014, Turku, Finland

    Sirpa Jalkanen

  5. UO Medicina Nucleare, Azienda Ospedaliero-Universitaria S.Orsola Malpighi, Pad. 30, Via Massarenti n.9, 40138, Bologna, Italy

    Cristina Nanni

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  1. Anne Roivainen
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Correspondence to Anne Roivainen.

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Roivainen, A., Jalkanen, S. & Nanni, C. Gallium-labelled peptides for imaging of inflammation. Eur J Nucl Med Mol Imaging 39 (Suppl 1), 68–77 (2012). https://doi.org/10.1007/s00259-011-1987-6

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  • DOI: https://doi.org/10.1007/s00259-011-1987-6

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