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Laparoscopic sentinel lymph node (SLN) versus extensive pelvic dissection for clinically localized prostate carcinoma

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

Lymph node metastasis is an important prognostic factor in prostate cancer (PC). The aim of this prospective study was to evaluate the accuracy of sentinel lymph node (SLN) biopsy by laparoscopy in staging locoregional patients with clinically localized PC.

Methods

A transrectal ultrasound-guided injection of 0.3 ml/100 MBq 99mTc-sulphur rhenium colloid in each prostatic lobe was performed the day before surgery. Detection was performed intraoperatively with a laparoscopic probe (Gamma Sup CLERAD®) followed by extensive resection. SLN counts were performed in vivo and confirmed ex vivo. Histological analysis was performed by haematoxylin-phloxine-saffron staining, followed by immunohistochemistry (IHC) if the SLN was free of metastasis.

Results

The study included 93 patients with PC at intermediate or high risk of lymph node metastases. The intraoperative detection rate was 93.5% (87/93). Nineteen patients had lymph node metastases, nine only in SLN. The false-negative rate was 10.5% (2/19). The internal iliac region was the primary metastatic site (43.3%). Metastatic sentinel nodes in the common iliac region beyond the ureteral junction were present in 13.3%. Limited or standard lymph node resection would have ignored 73.2 and 56.6% of lymph node metastases, respectively.

Conclusion

Laparoscopy is suitable for broad identification of SLN metastasis, and targeted resection of these lymph nodes significantly limits the risk of extended surgical resection whilst maintaining the accuracy of the information.

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Conflicts of interest

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Authors and Affiliations

  1. Médecine Nucléaire, ICO René Gauducheau, Boulevard Monod, 44805, Saint Herblain Cedex, France

    Caroline Rousseau, Boumédiène Bridji, Amandine Pallardy, Aude Testard, Ayat Mouaden & Françoise Kraeber-Bodéré

  2. CRCNA INSERM U892, Institut de recherche thérapeutique de l’Université de Nantes, 8 quai de Moncousu, BP 70721, 44007, Nantes Cedex 1, France

    Caroline Rousseau, Chantal Curtet & Françoise Kraeber-Bodéré

  3. Clinique Urologique Nantes-Atlantis, Ave J. Cartier, 44800, Saint-Herblain, France

    Thierry Rousseau & Jacques Lacoste

  4. Statistiques, ICO René Gauducheau, Bd Monod, 44805, Saint Herblain Cedex, France

    Loïc Campion

  5. Anatomopathologie, Institut d’Histopathologie, 55 rue Amiral du Chaffault, BP 50424, 44104, Nantes Cedex 4, France

    Geneviève Aillet

Authors
  1. Caroline Rousseau
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  2. Thierry Rousseau
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Corresponding author

Correspondence to Caroline Rousseau.

Additional information

This study has provided the basis for oral presentations or posters at the European Congress of Nuclear Medicine in Barcelona 2009, the European Congress of Urology in Barcelona 2010 and the European Congress of Nuclear Medicine in Vienna 2010.

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Rousseau, C., Rousseau, T., Bridji, B. et al. Laparoscopic sentinel lymph node (SLN) versus extensive pelvic dissection for clinically localized prostate carcinoma. Eur J Nucl Med Mol Imaging 39, 291–299 (2012). https://doi.org/10.1007/s00259-011-1975-x

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  • DOI: https://doi.org/10.1007/s00259-011-1975-x

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