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Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

We evaluated the diagnostic accuracy of attenuation corrected nuclear myocardial perfusion imaging (MPI) with a novel hybrid single photon emission computed tomography (SPECT)/CT device consisting of an ultrafast dedicated cardiac gamma camera with cadmium-zinc-telluride (CZT) solid-state semiconductor detectors integrated onto a multislice CT scanner to detect coronary artery disease (CAD). Invasive coronary angiography served as the standard of reference.

Methods

The study population included 66 patients (79% men; mean age 63 ± 11 years) who underwent 1-day 99mTc-tetrofosmin pharmacological stress/rest examination and angiography within 3 months. Sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) as well as accuracy of the CT X-ray based attenuation corrected CZT MPI for detection of CAD (≥50% luminal narrowing) was calculated on a per-patient basis.

Results

The prevalence of angiographic CAD in the study population was 82%. Sensitivity, specificity, PPV, NPV and accuracy were 87, 67, 92, 53 and 83%, respectively.

Conclusion

In this first report on CZT SPECT/CT MPI comparison versus angiography we confirm a high accuracy for detection of angiographically documented CAD.

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Acknowledgments

Financial contributions from the Swiss National Science Foundation (323630-128868/1 to M.F. and 320030-127604/1 to P.A.K.) are gratefully acknowledged. Furthermore, we thank Daisy Beutel, Serpil Bostanci-Kökylidirim, Mirjam De Bloeme, Edlira Loga, Ennio Mueller and Patrick von Schulthess for their technical support.

Conflicts of interest

The University Hospital Zurich holds a research contract with GE Healthcare.

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Authors and Affiliations

  1. Department of Radiology, Cardiac Imaging, University Hospital Zurich, Ramistrasse 100, 8091, Zurich, Switzerland

    Michael Fiechter, Jelena R. Ghadri, Silke M. Kuest, Aju P. Pazhenkottil, Mathias Wolfrum, Rene N. Nkoulou, Robert Goetti, Oliver Gaemperli & Philipp A. Kaufmann

  2. Zurich Center for Integrative Human Physiology (ZIHP), University of Zurich, Zurich, Switzerland

    Michael Fiechter & Philipp A. Kaufmann

Authors
  1. Michael Fiechter
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  2. Jelena R. Ghadri
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  3. Silke M. Kuest
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  4. Aju P. Pazhenkottil
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  5. Mathias Wolfrum
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  6. Rene N. Nkoulou
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  7. Robert Goetti
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  8. Oliver Gaemperli
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  9. Philipp A. Kaufmann
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Corresponding author

Correspondence to Philipp A. Kaufmann.

Additional information

Michael Fiechter and Jelena R. Ghadri contributed equally to this work.

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Fiechter, M., Ghadri, J.R., Kuest, S.M. et al. Nuclear myocardial perfusion imaging with a novel cadmium-zinc-telluride detector SPECT/CT device: first validation versus invasive coronary angiography. Eur J Nucl Med Mol Imaging 38, 2025–2030 (2011). https://doi.org/10.1007/s00259-011-1877-y

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  • DOI: https://doi.org/10.1007/s00259-011-1877-y

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