Skip to main content
SpringerLink
Log in

FDG-PET for early assessment of Alzheimer’s disease: isn’t the evidence base large enough?

  • Focus on...
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. www.ibro.info/media/pdf/si-his-pdf-pdf9.pdf.

  2. Alavi A, Reivich M, Ferris S, Christman D, Fowler J, MacGregor R, et al. Regional cerebral glucose metabolism in aging and senile dementia as determined by 18F-deoxyglucose and positron emission tomography. Exp Brain Res. 1982;Suppl 5:187–95.

    Google Scholar 

  3. http://www.adni-info.org/Home.aspx.

  4. Jagust WJ, Bandy D, Chen K, Foster NL, Landau SM, Mathis CA, et al. Alzheimer’s Disease Neuroimaging Initiative. The Alzheimer’s Disease Neuroimaging Initiative positron emission tomography core. Alzheimers Dement. 2010;6(3):221–9.

    Article  PubMed  Google Scholar 

  5. Mistur R, Mosconi L, Santi SD, Guzman M, Li Y, Tsui W, et al. Current challenges for the early detection of Alzheimer’s disease: brain imaging and CSF studies. J Clin Neurol. 2009;5(4):153–66.

    Article  PubMed  Google Scholar 

  6. Walhovd KB, Fjell AM, Brewer J, McEvoy LK, Fennema-Notestine C, Hagler Jr DJ, et al. Alzheimer’s Disease Neuroimaging Initiative. Combining MR imaging, positron-emission tomography, and CSF biomarkers in the diagnosis and prognosis of Alzheimer disease. AJNR Am J Neuroradiol. 2010;31(2):347–54.

    Article  CAS  PubMed  Google Scholar 

  7. Jagust WJ, Landau SM, Shaw LM, Trojanowski JQ, Koeppe RA, Reiman EM, et al. Alzheimer’s Disease Neuroimaging Initiative. Relationships between biomarkers in aging and dementia. Neurology 2009;73(15):1193–9.

    Article  CAS  PubMed  Google Scholar 

  8. Morbelli S, Piccardo A, Villavecchia G, Dessi B, Brugnolo A, Piccini A, et al. Mapping brain morphological and functional conversion patterns in amnestic MCI: a voxel-based MRI and FDG-PET study. Eur J Nucl Med Mol Imaging. 2010;37(1):36–45.

    Article  PubMed  Google Scholar 

  9. Lowe VJ, Kemp BJ, Jack Jr CR, Senjem M, Weigand S, Shiung M, et al. Comparison of 18F-FDG and PiB PET in cognitive impairment. J Nucl Med. 2009;50(6):878–86.

    Article  PubMed  Google Scholar 

  10. Chen K, Langbaum JB, Fleisher AS, Ayutyanont N, Reschke C, Lee W, et al. Alzheimer’s Disease Neuroimaging Initiative. Twelve-month metabolic declines in probable Alzheimer’s disease and amnestic mild cognitive impairment assessed using an empirically pre-defined statistical region-of-interest: findings from the Alzheimer’s Disease Neuroimaging Initiative. Neuroimage 2010;51(2):654–64.

    Article  PubMed  Google Scholar 

  11. Haense C, Herholz K, Jagust WJ, Heiss WD. Performance of FDG PET for detection of Alzheimer’s disease in two independent multicentre samples (NEST-DD and ADNI). Dement Geriatr Cogn Disord. 2009;28(3):259–66.

    Article  CAS  PubMed  Google Scholar 

  12. Yuan X, Shan B, Ma Y, Tian J, Jiang K, Cao Q, et al. Multi-center study on Alzheimer’s disease using FDG PET: group and individual analyses. J Alzheimers Dis. 2010;19(3):927–35.

    CAS  PubMed  Google Scholar 

  13. Panegyres PK, Rogers JM, McCarthy M, Campbell A, Wu JS. Fluorodeoxyglucose-positron emission tomography in the differential diagnosis of early-onset dementia: a prospective, community-based study. BMC Neurol. 2009;9:41.

    Article  PubMed  Google Scholar 

  14. Langbaum JB, Chen K, Lee W, Reschke C, Bandy D, Fleisher AS, et al. Alzheimer’s Disease Neuroimaging Initiative. Categorical and correlational analyses of baseline fluorodeoxyglucose positron emission tomography images from the Alzheimer’s Disease Neuroimaging Initiative (ADNI). Neuroimage 2009;45(4):1107–16.

    Article  PubMed  Google Scholar 

  15. Pagani M, Dessi B, Morbelli S, Brugnolo A, Salmaso D, Piccini A, et al. MCI patients declining and not-declining at mid-term follow-up: FDG-Pet findings. Curr Alzheimer Res. 2009 Nov 26.

  16. Clerici F, Del Sole A, Chiti A, Maggiore L, Lecchi M, Pomati S, et al. Differences in hippocampal metabolism between amnestic and non-amnestic MCI subjects: automated FDG-PET image analysis. Q J Nucl Med Mol Imaging. 2009;53(6):646–57.

    CAS  PubMed  Google Scholar 

  17. Silverman DH, Small GW, Chang CY, Lu CS, Kung De Aburto MA, Chen W, et al. Positron emission tomography in evaluation of dementia: regional brain metabolism and long-term outcome. JAMA 2001;286(17):2120–7.

    Article  CAS  PubMed  Google Scholar 

  18. http://www.emea.europa.eu/pdfs/conferenceflyers/51256206en.pdf.

  19. Waldemar G, Dubois B, Emre M, Georges J, McKeith IG, Rossor M, et al. Recommendations for the diagnosis and management of Alzheimer’s disease and other disorders associated with dementia: EFNS guideline. Eur J Neurol. 2007;14:e1–e26.

    Article  CAS  PubMed  Google Scholar 

  20. Mosconi L, Tsui WH, Herholz K, Pupi A, Drzezga A, Lucignani G, et al. Multicenter standardized 18F-FDG PET diagnosis of mild cognitive impairment, Alzheimer’s disease, and other dementias. J Nucl Med. 2008;49(3):390–8.

    Article  PubMed  Google Scholar 

  21. Durand-Martel P, Tremblay D, Brodeur C, Paquet N. Autopsy as gold standard in FDG-PET studies in dementia. Can J Neurol Sci. 2010;37(3):336–42.

    PubMed  Google Scholar 

Download references

Acknowledgement

The authors are grateful to Ms Catherine Wrenn for her advice and skilful editorial support.

Author information

Authors and Affiliations

  1. Department of Biomedical Sciences and Technologies and Center of Molecular and Cellular Imaging (IMAGO), University of Milan, Milan, Italy

    Giovanni Lucignani

  2. Department of Diagnostic Services, Unit of Nuclear Medicine, San Paolo Hospital, Via Antonio di Rudinì, 8, 20142, Milan, Italy

    Giovanni Lucignani

  3. Department of Neurosciences, Ophthalmology and Genetics, Clinical Neurophysiology Unit, University of Genoa, Genoa, 516132, Italy

    Flavio Nobili

Authors
  1. Giovanni Lucignani
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Flavio Nobili
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Giovanni Lucignani.

Additional information

“Focus on…” abridgements aim to highlight papers published within the past year and draw extensively on the texts and summaries of the articles referenced. Less recent citations are also included when deemed useful to provide background information on the topic reviewed.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lucignani, G., Nobili, F. FDG-PET for early assessment of Alzheimer’s disease: isn’t the evidence base large enough?. Eur J Nucl Med Mol Imaging 37, 1604–1609 (2010). https://doi.org/10.1007/s00259-010-1535-9

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00259-010-1535-9

Keywords

Search

Navigation