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Simultaneous dual-radionuclide myocardial perfusion imaging with a solid-state dedicated cardiac camera

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

We compared simultaneous dual-radionuclide (DR) stress and rest myocardial perfusion imaging (MPI) with a novel solid-state cardiac camera and a conventional SPECT camera with separate stress and rest acquisitions.

Methods

Of 27 consecutive patients recruited, 24 (64.5±11.8 years of age, 16 men) were injected with 74 MBq of 201Tl (rest) and 250 MBq 99mTc-MIBI (stress). Conventional MPI acquisition times for stress and rest are 21 min and 16 min, respectively. Rest 201Tl for 6 min and simultaneous DR 15-min list mode gated scans were performed on a D-SPECT cardiac scanner. In 11 patients DR D-SPECT was performed first and in 13 patients conventional stress 99mTc-MIBI SPECT imaging was performed followed by DR D-SPECT. The DR D-SPECT data were processed using a spill-over and scatter correction method. DR D-SPECT images were compared with rest 201Tl D-SPECT and with conventional SPECT images by visual analysis employing the 17-segment model and a five-point scale (0 normal, 4 absent) to calculate the summed stress and rest scores. Image quality was assessed on a four-point scale (1 poor, 4 very good) and gut activity was assessed on a four-point scale (0 none, 3 high).

Results

Conventional MPI studies were abnormal at stress in 17 patients and at rest in 9 patients. In the 17 abnormal stress studies DR D-SPECT MPI showed 113 abnormal segments and conventional MPI showed 93 abnormal segments. In the nine abnormal rest studies DR D-SPECT showed 45 abnormal segments and conventional MPI showed 48 abnormal segments. The summed stress and rest scores on conventional SPECT and DR D-SPECT were highly correlated (r=0.9790 and 0.9694, respectively). The summed scores of rest 201Tl D-SPECT and DR-DSPECT were also highly correlated (r=0.9968, p<0.0001 for all). In six patients stress perfusion defects were significantly larger on stress DR D-SPECT images, and five of these patients were imaged earlier by D-SPECT than by conventional SPECT.

Conclusion

Fast and high-quality simultaneous DR MPI is feasible with D-SPECT in a single imaging session with comparable diagnostic performance and image quality to conventional SPECT and to a separate rest 201Tl D-SPECT acquisition.

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Acknowledgments

We thank Dalia Dickman, Dalia Shiti and Samy Bross at Spectrum Dynamics for their assistance in the preparation of the manuscript. This work was undertaken at UCLH/UCL which received a proportion of the funding from the Department of Health's NIHR Biomedical Research Centres funding scheme. Dr. Daniel Berman owns shares in Spectrum Dynamics and is a member of the Medical Advisory Board and consultant for Spectrum Dynamics. Dr. Brian Hutton is a member of Spectrum Dynamics Technical Advisory Board.

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Authors and Affiliations

  1. Institute of Nuclear Medicine, University College London Hospitals NHS Trust, 235 Euston Road, London, NW1 2BU, UK

    Simona Ben-Haim, Krzysztof Kacperski, Sharon Hain, Dean Van Gramberg, Brian F. Hutton, Kjell Erlandsson, Wendy A. Waddington & Peter J. Ell

  2. Procardia-Maccabi Healthcare Services, Tel Aviv, Israel

    Tali Sharir

  3. Spectrum Dynamics, Caesarea, Israel

    Nathaniel Roth

  4. Cedars Sinai Medical Center, Los Angeles, CA, USA

    Daniel S. Berman

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  1. Simona Ben-Haim
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  2. Krzysztof Kacperski
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  3. Sharon Hain
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  4. Dean Van Gramberg
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  5. Brian F. Hutton
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  6. Kjell Erlandsson
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  7. Tali Sharir
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  8. Nathaniel Roth
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  9. Wendy A. Waddington
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  10. Daniel S. Berman
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  11. Peter J. Ell
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Correspondence to Simona Ben-Haim.

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Ben-Haim, S., Kacperski, K., Hain, S. et al. Simultaneous dual-radionuclide myocardial perfusion imaging with a solid-state dedicated cardiac camera. Eur J Nucl Med Mol Imaging 37, 1710–1721 (2010). https://doi.org/10.1007/s00259-010-1441-1

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  • DOI: https://doi.org/10.1007/s00259-010-1441-1

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