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Dynamic perfusion patterns in temporal lobe epilepsy

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

To investigate dynamic ictal perfusion changes during temporal lobe epilepsy (TLE).

Methods

We investigated 37 patients with TLE by ictal and interictal SPECT. All ictal injections were performed within 60 s of seizure onset. Statistical parametric mapping was used to analyse brain perfusion changes and temporal relationships with injection time and seizure duration as covariates.

Results

The analysis revealed significant ictal hyperperfusion in the ipsilateral temporal lobe extending to subcortical regions. Hypoperfusion was observed in large extratemporal areas. There were also significant dynamic changes in several extratemporal regions: ipsilateral orbitofrontal and bilateral superior frontal gyri and the contralateral cerebellum and ipsilateral striatum.

Conclusion

The study demonstrated early dynamic perfusion changes in extratemporal regions probably involved in both propagation of epileptic activity and initiation of inhibitory mechanisms.

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Acknowledgments

This work was conducted within the framework of a Coordinated Research Project (CRP E1.30.21) of the International Atomic Energy Agency (IAEA) and supported by IAEA contract BEL-12546.

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Correspondence to John J. Zaknun.

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Dupont, P., Zaknun, J.J., Maes, A. et al. Dynamic perfusion patterns in temporal lobe epilepsy. Eur J Nucl Med Mol Imaging 36, 823–830 (2009). https://doi.org/10.1007/s00259-008-1040-6

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  • DOI: https://doi.org/10.1007/s00259-008-1040-6

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