Skip to main content
SpringerLink
Log in

Correlation of immunohistopathological expression of somatostatin receptor 2 with standardised uptake values in 68Ga-DOTATOC PET/CT

  • Short Communication
  • Published:
European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract

Purpose

In clinical routine somatostatin analogue positron emission tomography/computed tomography (PET/CT) such as 68Ga-DOTA-Tyr-octreotide (DOTATOC)-PET/CT could substitute conventional 111In-Octreotide scintigraphy. Immunohistochemistry (IHC) for somatostatin receptor 2 (SSTR2) might be a tool to predict positivity of 68Ga-DOTATOC in patients where initial staging was not performed, e.g., in incidental findings. We therefore compared a score of SSTR2-IHC with the in vivo standard uptake value (SUV) of preoperative or prebiopsy 68Ga-DOTATOC PET/CT.

Materials and methods

In 18 patients, 68Ga-DOTATOC PET/CT scans were quantified with SUV calculations and correlated to a cell membrane-based SSTR2-IHC score (ranging from 0 to 3).

Results

Negative IHC scores were consistent with SUV values below 10. Furthermore, all score 2 and 3 specimens corresponded with high SUV values (above 15).

Conclusion

SSTR2-IHC scores correlated well with SUV values and we propose to use SSTR2 immunohistochemistry in patients missing a preoperative PET scan to indicate 68Ga-DOTATOC-PET/CT as method for restaging and follow-up in individual patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Krenning EP, Valkema R, Kwekkeboom DJ, de Herder WW, van Eijck CH, de Jong M, Pauwels S, Reubi JC. Molecular imaging as in vivo molecular pathology for gastroenteropancreatic neuroendocrine tumors: implications for follow-up after therapy. J Nucl Med 2005;46(Suppl 1):76S–82S.

    PubMed  Google Scholar 

  2. Kwekkeboom DJ, Krenning EP. Radiolabeled somatostatin analog scintigraphy in oncology and immune diseases: an overview. Eur Radiol 1997;7(7):1103–9.

    Article  PubMed  CAS  Google Scholar 

  3. van der Lely AJ, de Herder WW, Krenning EP, Kwekkeboom DJ. Octreoscan radioreceptor imaging. Endocrine 2003;20(3):307–11.

    Article  PubMed  Google Scholar 

  4. Antunes P, Ginj M, Zhang H, Waser B, Baum RP, Reubi JC, Maecke H. Are radiogallium-labelled DOTA-conjugated somatostatin analogues superior to those labelled with other radiometals? Eur J Nucl Med Mol Imaging 2007;34(7):982–93.

    Article  PubMed  CAS  Google Scholar 

  5. Reubi JC, Schar JC, Waser B, Wenger S, Heppeler A, Schmitt JS, Macke HR. Affinity profiles for human somatostatin receptor subtypes SST1-SST5 of somatostatin radiotracers selected for scintigraphic and radiotherapeutic use. Eur J Nucl Med 2000;27(3):273–82.

    Article  PubMed  CAS  Google Scholar 

  6. Steinmuller T, Kianmanesh R, Falconi M, Scarpa A, Taal B, Kwekkeboom DJ, Lopes JM, Perren A, Nikou G, Yao J. Consensus guidelines for the management of patients with liver metastases from digestive (neuro)endocrine tumors: foregut, midgut, hindgut, and unknown primary. Neuroendocrinology 2008;87(1):47–62.

    Article  PubMed  Google Scholar 

  7. Buchmann I, Henze M, Engelbrecht S, Eisenhut M, Runz A, Schafer M, Schilling T, Haufe S, Herrmann T, Haberkorn U. Comparison of 68Ga-DOTATOC PET and 111In-DTPAOC (Octreoscan) SPECT in patients with neuroendocrine tumours. Eur J Nucl Med Mol Imaging 2007;34(10):1617–26.

    Article  PubMed  CAS  Google Scholar 

  8. Volante M, Brizzi MP, Faggiano A, La Rosa S, Rapa I, Ferrero A, Mansueto G, Righi L, Garancini S, Capella C. Somatostatin receptor type 2A immunohistochemistry in neuroendocrine tumors: a proposal of scoring system correlated with somatostatin receptor scintigraphy. Mod Pathol 2007;20(11):1172–82.

    Article  PubMed  CAS  Google Scholar 

  9. Asnacios A, Courbon F, Rochaix P, Bauvin E, Cances-Lauwers V, Susini C, Schulz S, Boneu A, Guimbaud R, Buscail L. Indium-111-pentetreotide scintigraphy and somatostatin receptor subtype 2 expression: new prognostic factors for malignant well-differentiated endocrine tumors. J Clin Oncol 2008;26(6):963–70.

    Article  PubMed  Google Scholar 

  10. Wieder H, Beer AJ, Poethko T, Meisetschlaeger G, Wester HJ, Rummeny E, Schwaiger M, Stahl AR. PET/CT with Gluc-Lys-([(18)F]FP)-TOCA: correlation between uptake, size and arterial perfusion in somatostatin receptor positive lesions. Eur J Nucl Med Mol Imaging 2008;35(2):264–71.

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Nuclear Medicine, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675, München, Germany

    Matthias Miederer, Andreas Buck, Klemens Scheidhauer, Hans-Jürgen Wester & Markus Schwaiger

  2. Department of Pathology, Klinikum rechts der Isar, Technische Universität München, Ismaningerstrasse 22, 81675, München, Germany

    Stefan Seidl & Aurel Perren

Authors
  1. Matthias Miederer
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Stefan Seidl
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Andreas Buck
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Klemens Scheidhauer
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hans-Jürgen Wester
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Markus Schwaiger
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Aurel Perren
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Matthias Miederer.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Miederer, M., Seidl, S., Buck, A. et al. Correlation of immunohistopathological expression of somatostatin receptor 2 with standardised uptake values in 68Ga-DOTATOC PET/CT. Eur J Nucl Med Mol Imaging 36, 48–52 (2009). https://doi.org/10.1007/s00259-008-0944-5

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00259-008-0944-5

Keywords

Search

Navigation