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EANM Dosimetry Committee series on standard operational procedures for pre-therapeutic dosimetry I: blood and bone marrow dosimetry in differentiated thyroid cancer therapy

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Abstract

Introduction

The purpose of the EANM Dosimetry Committee Series on “Standard Operational Procedures for Pre-therapeutic Dosimetry” (SOP) is to provide advice to scientists and clinicians on how to perform pre-therapeutic and/or therapeutic patient-specific absorbed dose assessments.

Material and Methods

This particular SOP gives advice on how to tailor the therapeutic activity to be administered for systemic treatment of differentiated thyroid cancer (DTC) such that the absorbed dose to the blood does not exceed 2 Gy (a widely accepted limit for bone marrow toxicity). The methodology of blood-based dosimetry has been developed in the 1960s and refined in a series of international multi-centre trials in the framework of the introduction of new diagnostic and therapeutic tools, e.g. recombinant human thyroid-stimulating hormone in the management of DTC.

Conclusion

The intention is to guide the user through a series of measurements and calculations which the authors consider to be the best and most reproducible way at present.

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Acknowledgment

This work was developed under the close supervision of the Dosimetry Committee of the EANM (M Bardiès, C Chiesa, G Flux, S-E Strand, S Savolainen, M Monsieurs and M Lassmann).

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Authors and Affiliations

  1. Department of Nuclear Medicine, University Hospital Würzburg, Würzburg, Germany

    Michael Lassmann, Heribert Hänscheid & Markus Luster

  2. Nuclear Medicine Department, Istituto Nazionale Tumori, Milan, Italy

    Carlo Chiesa

  3. Joint Department of Physics, The Royal Marsden NHS Foundation Trust and Institute of Cancer Research, Sutton, Surrey, UK

    Cecilia Hindorf & Glenn Flux

  4. Josef-Schneider-Str. 2, 97080, Würzburg, Germany

    Michael Lassmann

Authors
  1. Michael Lassmann
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  2. Heribert Hänscheid
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  3. Carlo Chiesa
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  4. Cecilia Hindorf
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  5. Glenn Flux
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  6. Markus Luster
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Corresponding author

Correspondence to Michael Lassmann.

Additional information

Michael Lassmann, Carlo Chiesa and Glenn Flux are members of the EANM Dosimetry Committee.

Markus Luster is a member of the EANM Therapy Committee.

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Lassmann, M., Hänscheid, H., Chiesa, C. et al. EANM Dosimetry Committee series on standard operational procedures for pre-therapeutic dosimetry I: blood and bone marrow dosimetry in differentiated thyroid cancer therapy. Eur J Nucl Med Mol Imaging 35, 1405–1412 (2008). https://doi.org/10.1007/s00259-008-0761-x

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  • DOI: https://doi.org/10.1007/s00259-008-0761-x

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