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11C-acetate PET in the early evaluation of prostate cancer recurrence

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Abstract

Purpose

The first aim of the study was to investigate the diagnostic potential of 11C-acetate PET in the early detection of prostate cancer recurrence. A second aim was the evaluation of early and late PET in this context.

Methods

The study population comprised 32 prostate cancer patients with early evidence of relapse after initial radiotherapy (group A) or radical surgery (group B). The median PSA of group A (n=17) patients was 6 ng/ml (range 2.6–30.2) while that of group B (n=15) was 0.4 ng/ml (range 0.08–4.8). Pelvic-abdominal-thoracic PET was started 2 min after injection of 11C-acetate and evaluated after fusion with CT.

Results

Group A: Taking a SUVmax≥2 as the cut-off, PET showed local recurrences in 14/17 patients and two equivocal results. Distant disease was observed in six patients and an equivocal result was obtained in one. Endorectal MRI was positive in 12/12 patients. Biopsy confirmed local recurrence in six of six (100%) patients. PET was positive in five of the six patients with biopsy-proven recurrences, the result in the remaining patient being equivocal. Group B: Among the 15 patients, visual interpretation was positive for local recurrences in five patients and equivocal in four. One obturator lymph node was positive. Endorectal MRI was positive in 11/15 patients and equivocal in two. Positional correlation of positive/equivocal results on PET and endorectal MRI was observed in seven of nine patients. PSA decreased significantly after salvage radiotherapy in 8/14 patients, providing strong evidence for local recurrence. PET of the eight patients responding to RT was positive in three and equivocal in two.

Conclusion

11C-acetate PET was found to be valuable in the early evaluation of prostate cancer relapse. Optimising scanning time and use of modern PET-CT equipment might allow further improvement.

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Acknowledgements

We acknowledge with thanks the generous donation from the foundation Cellex International that made this study possible. We also express our gratitude to the staff of the services of nuclear medicine and radiology who performed the imaging and to Mrs. Frances Godson for reviewing the manuscript.

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Authors and Affiliations

  1. Service of Nuclear Medicine, University Hospital of Geneva, Rue Micheli-du-Crest 24, 1211, Geneva 14, Switzerland

    Susanne Albrecht, Franz Buchegger, Dmitri Soloviev, Habib Zaidi, Alain Keller & Osman Ratib

  2. Service of Nuclear Medicine, University Hospital of Lausanne, Lausanne, Switzerland

    Franz Buchegger & Angelika Bischof Delaloye

  3. Service of Radiation Oncology, University Hospital of Geneva, Geneva, Switzerland

    Hansjoerg Vees & Raymond Miralbell

  4. Institute of Radiology Jean Violette, Geneva, Switzerland

    Haleem G. Khan

  5. Instituto Oncológico Teknon, Barcelona, Spain

    Raymond Miralbell

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  1. Susanne Albrecht
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  2. Franz Buchegger
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Correspondence to Susanne Albrecht.

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Albrecht, S., Buchegger, F., Soloviev, D. et al. 11C-acetate PET in the early evaluation of prostate cancer recurrence. Eur J Nucl Med Mol Imaging 34, 185–196 (2007). https://doi.org/10.1007/s00259-006-0163-x

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  • DOI: https://doi.org/10.1007/s00259-006-0163-x

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