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18F-FDG PET in children with lymphomas

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Abstract

Purpose

The aim of this study was to retrospectively evaluate the performance of positron emission tomography (PET) with 18F-fluorodeoxyglucose (18F-FDG) in children with lymphomas, at various stages of their disease.

Methods

Twenty-eight children (mean age 12.5 years, 14 girls, 14 boys) with Hodgkin’s disease (HD, n=17) or non-Hodgkin’s lymphoma (NHL, n=11) were evaluated. Patients were investigated at initial staging (n=19), early in the course of treatment (n=19), at the end of treatment (n=16) and during long-term follow-up (n=19). A total of 113 whole-body PET studies were performed on dedicated scanners. PET results were compared with the results of conventional methods (CMs) such as physical examination, laboratory studies, chest X-rays, computed tomography, magnetic resonance imaging, ultrasonography and bone scan when available.

Results

At initial evaluation (group 1), PET changed the disease stage and treatment in 10.5% of the cases. In early evaluation of the response to treatment (group 2), PET failed to predict two relapses and one incomplete response to treatment. In this group, however, PET did not show any false positive results. There were only 4/75 false positive results for PET among patients studied at the end of treatment (group 3, specificity 94%) or during the systematic follow-up (group 4, specificity 95%), as compared with 27/75 for CMs (specificity 54% and 66%, respectively).

Conclusion

18F-FDG-PET is a useful tool for evaluating children with lymphomas. Large prospective studies are needed to appreciate its real impact on patient management.

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Authors and Affiliations

  1. Division of Nuclear Medicine, University Hospital, Liège, Belgium

    Gisele Depas, Caroline De Barsy, Jacqueline Foidart, Pierre Rigo & Roland Hustinx

  2. Division of Medical Oncology, University Hospital, Liège, Belgium

    Guy Jerusalem

  3. Division of Pediatric Hematology and Oncology, CHR Citadelle, Liège, Belgium

    Claire Hoyoux & Marie-Françoise Dresse

  4. Division of Hematology, University Hospital, Liège, Belgium

    Marie-France Fassotte

  5. Division of Nuclear Medicine, Hôtel de Dieu, Lévis, Québec, Canada

    Nancy Paquet

Authors
  1. Gisele Depas
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  2. Caroline De Barsy
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  3. Guy Jerusalem
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  4. Claire Hoyoux
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  5. Marie-Françoise Dresse
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  6. Marie-France Fassotte
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  7. Nancy Paquet
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  9. Pierre Rigo
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Correspondence to Gisele Depas.

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Depas, G., De Barsy, C., Jerusalem, G. et al. 18F-FDG PET in children with lymphomas. Eur J Nucl Med Mol Imaging 32, 31–38 (2005). https://doi.org/10.1007/s00259-004-1604-z

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  • DOI: https://doi.org/10.1007/s00259-004-1604-z

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