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FDG-PET/CT in re-staging of patients with lymphoma

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Abstract

The aim of this study was to evaluate the clinical significance of combined fluorine-18 fluorodeoxyglucose positron emission tomography and computed tomography (FDG-PET/CT) in patients with lymphoma, and to compare the FDG-PET/CT staging results with those of FDG-PET and CT alone. Twenty-seven patients were studied. Each patient had clinical follow-up for >12 months and entered complete follow-up evaluation. Patient-based evaluation showed a sensitivity of 78% for CT alone, 86% for FDG-PET alone, 93% for CT and FDG-PET read side by side, and 93% for combined FDG-PET/CT imaging. Region-based evaluation showed a sensitivity for regional lymph node involvement of 61%, 78%, 91% and 96% respectively. FDG-PET/CT imaging is superior to CT alone (P=0.02) and has additional benefit over FDG-PET alone due to exact anatomical localisation. We conclude that FDG-PET/CT imaging is accurate in re-staging lymphoma and offers advantages over separate FDG-PET and CT imaging.

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Fig. 1A–C
Fig. 2A, B

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Acknowledgements

The authors thank D. Porsch-Plottek and B. Terschüren for their assistance with the data acquisition.

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Authors and Affiliations

  1. Clinic and Policlinic for Nuclear Medicine, University of Essen, Hufelandstrasse 55, 45122, Essen, Germany

    L. S. Freudenberg, T. Beyer, W. Jentzen, S. P. Müller, R. Görges & A. Bockisch

  2. Department of Radiology, University of Essen, Essen, Germany

    G. Antoch & J. F. Debatin

  3. Department of Internal Medicine (Cancer Research), University of Essen, Essen, Germany

    P. Schütt & M. R. Nowrousian

Authors
  1. L. S. Freudenberg
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  2. G. Antoch
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  3. P. Schütt
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  4. T. Beyer
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  5. W. Jentzen
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  6. S. P. Müller
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  7. R. Görges
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  8. M. R. Nowrousian
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  9. A. Bockisch
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  10. J. F. Debatin
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Correspondence to L. S. Freudenberg.

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Freudenberg, L.S., Antoch, G., Schütt, P. et al. FDG-PET/CT in re-staging of patients with lymphoma. Eur J Nucl Med Mol Imaging 31, 325–329 (2004). https://doi.org/10.1007/s00259-003-1375-y

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  • DOI: https://doi.org/10.1007/s00259-003-1375-y

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