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Sarcoma tumor FDG uptake measured by PET and patient outcome: a retrospective analysis

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European Journal of Nuclear Medicine and Molecular Imaging Aims and scope Submit manuscript

Abstract.

In a retrospective analysis of patients with sarcoma who underwent fluorodeoxyglucose positron emission tomography (FDG PET) imaging, tumor maximum FDG uptake was analyzed for ability to predict patient survival and disease-free interval. Two hundred and nine patients with sarcoma were imaged prior to treatment with neoadjuvant chemotherapy or resection. Tumor FDG uptake expressed as maximum standard uptake value (SUVmax) was compared with disease-free and overall survival. A multivariate Cox regression analysis was applied to examine the role of SUVmax in predicting time to death or disease progression, after adjusting for standard clinical prognostic factors. The multivariate analyses showed that the SUVmax information is a statistically significant independent predictor of patient survival. Tumors with larger SUVmax have a significantly poorer prognosis. This retrospective analysis indicates that the sarcoma tumor SUVmax value determined by PET is an independent predictor of survival and disease progression.

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Authors and Affiliations

  1. University of Washington Medical Center, Division of Nuclear Medicine, Box 356113, Seattle WA 98195-6113, Washington, USA, USA

    Janet F. Eary & Cheryl Vernon

  2. University College, Department of Statistics, Cork, Ireland, Ireland

    Finbarr O'Sullivan, Yudi Powitan & Kingshuk Chandhury

  3. University of Washington Medical Center, Department of Orthopedics, Seattle, Washington, USA, USA

    James D. Bruckner & Ernest U. Conrad

Authors
  1. Janet F. Eary
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  2. Finbarr O'Sullivan
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  3. Yudi Powitan
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  4. Kingshuk Chandhury
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  5. Cheryl Vernon
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  6. James D. Bruckner
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  7. Ernest U. Conrad
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Additional information

Received 26 January and in revised form 9 April 2002

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Eary, J.F., O'Sullivan, F., Powitan, Y. et al. Sarcoma tumor FDG uptake measured by PET and patient outcome: a retrospective analysis. Eur J Nucl Med 29, 1149–1154 (2002). https://doi.org/10.1007/s00259-002-0859-5

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  • DOI: https://doi.org/10.1007/s00259-002-0859-5

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