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Use of apparent diffusion coefficient as a response biomarker in bone: effect of developing sclerosis on quantified values

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Abstract

Objective

To investigate the effect of sclerosis on apparent diffusion coefficient measurements in bone metastases from prostate cancer undergoing treatment.

Materials and methods

Sixteen patients underwent CT scans and MRI at baseline and 12 weeks following commencement of chemotherapy. For each patient, up to five bone metastases were selected. Hounsfield units were measured on CT and apparent diffusion coefficient (ADC) was measured on diffusion weighted MRI at both time points. Correlations between changes in apparent diffusion coefficient and Hounsfield units were investigated.

Results

Corresponding pre- and post-treatment apparent diffusion coefficient and Hounsfield units were available on 60 lesions from 16 patients. Overall, there was no significant correlation between changes in apparent diffusion coefficient with Hounsfield units. However, where changes in Hounsfield units increased by more than 50 %, there was a trend for an associated ADC rise.

Conclusions

Increasing sclerosis of bone metastases on treatment does not significantly impede diffusion.

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Acknowledgments

We acknowledge the support received for the CRUK and EPSRC Cancer Imaging Centre in association with the MRC and department of Health (England) grant C1060/A10334 and also NHS funding to the NIHR Biomedical Research Centre.

Conflict of interest

The authors declare they have no conflicts of interest.

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Authors and Affiliations

  1. The Royal Marsden NHS Foundation Trust, Downs Road, Sutton, Surrey, SM2 5PT, UK

    C. Messiou, D. J. Collins, V. A. Morgan, D. Bianchini, J. S. de Bono & N. M. de Souza

  2. Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK

    J. S. de Bono & N. M. de Souza

  3. Department of Radiology, The Royal Marsden Hospital, Downs Rd, Surrey, SM2 5PT, UK

    C. Messiou

Authors
  1. C. Messiou
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  2. D. J. Collins
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  3. V. A. Morgan
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  4. D. Bianchini
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  5. J. S. de Bono
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  6. N. M. de Souza
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Corresponding author

Correspondence to C. Messiou.

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Messiou, C., Collins, D.J., Morgan, V.A. et al. Use of apparent diffusion coefficient as a response biomarker in bone: effect of developing sclerosis on quantified values. Skeletal Radiol 43, 205–208 (2014). https://doi.org/10.1007/s00256-013-1768-3

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  • DOI: https://doi.org/10.1007/s00256-013-1768-3

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