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The EGF-TM7 family: a postgenomic view

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Abstract

With the human and mouse genome projects now completed, the receptor repertoire of mammalian cells has finally been elucidated. The EGF-TM7 receptors are a family of class B seven-span transmembrane (TM7) receptors predominantly expressed by cells of the immune system. Within the large TM7 superfamily, the molecular structure and ligand-binding properties of EGF-TM7 receptors are unique. Derived from the processing of a single polypeptide, they are expressed at the cell surface as heterodimers consisting of a large extracellular region associated with a TM7 moiety. Through a variable number of N-terminal epidermal growth factor (EGF)-like domains, EGF-TM7 receptors interact with cellular ligands such as CD55 and chondroitin sulfate. Recent in vivo studies demonstrate a role of the EGF-TM7 receptor CD97 in leukocyte migration. The different number of EGF-TM7 genes in man compared with mice, the chimeric nature of EMR2 and the inactivation of human EMR4 point toward a still-evolving receptor family. Here we discuss the currently available information on this intriguing receptor family.

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Acknowledgements

We thank René A.W. van Lier for his comments and suggestions, Lisa A. Gilhuijs-Pederson for help with the phylogenetic analysis and Laurie Gordon for the information about the locus position of the EGF-TM7 genes. This work was supported by grants from the Netherlands Organization for Scientific Research (NWO, 901-07-208), the Landsteiner Foundation for Bloodtransfusion Research (LSBR, 0109), the Dutch Arthritis Association (RF, 99-2-14), the Wellcome Trust and the British Heart Foundation (PG/02/144). J.H. is a fellow of the Royal Netherlands Academy of Arts and Sciences.

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  1. Laboratory for Experimental Immunology, Academic Medical Center, University of Amsterdam, G1-106, P.O. Box 22700, 1100 DE , Amsterdam, The Netherlands

    Mark J. Kwakkenbos, Else N. Kop, Mourad Matmati & Jörg Hamann

  2. Division of Clinical Immunology and Rheumatology, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands

    Else N. Kop

  3. Sir William Dunn School of Pathology, University of Oxford, Oxford, UK

    Martin Stacey, Siamon Gordon & Hsi-Hsien Lin

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  1. Mark J. Kwakkenbos
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Correspondence to Jörg Hamann.

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Kwakkenbos, M.J., Kop, E.N., Stacey, M. et al. The EGF-TM7 family: a postgenomic view. Immunogenetics 55, 655–666 (2004). https://doi.org/10.1007/s00251-003-0625-2

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