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Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease—added value of low-dose CT

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Abstract

Background

Interim 18F-FDG PET helps predict outcome and tailor treatment in adults with Hodgkin disease (HD).

Objective

The purpose of this study was to assess predictive values of interim 18F-FDG PET/CT in children with HD and to define the potential added value to interim PET of low-dose CT.

Materials and methods

Children were prospectively enrolled August 2002–April 2007. PET/low-dose CT was performed at staging, after 2 cycles, at the end of treatment and during follow-up (mean 45 months). Treatment was unchanged regardless of interim results. PET and low-dose CT were read independently.

Results

Of 34 enrolled children (ages 3–17 years), 27 achieved complete response, 4 had progressive disease and 3 had relapse. Interim PET alone had positive and negative predictive values of 67% and 89%, respectively. Interim low-dose CT alone had positive and negative predictive values of 35% and 100%, respectively. Interim PET/CT had positive and negative predictive values of 75% and 96%, respectively.

Conclusions

Early interim PET/CT was a good predictor of outcome. Integrated PET and low-dose CT improved the predictive value in children with HD.

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Authors and Affiliations

  1. Department of Diagnostic Imaging, Rambam Health Care Campus, Haifa, Israel

    Anat Ilivitzki

  2. Department of Nuclear Medicine, Rambam Health Care Campus, Haifa, Israel

    Lea Radan & Ora Israel

  3. Department of Pediatric Oncology, Rambam Health Care Campus, Haifa, Israel

    Miriam Ben-Arush & Ayelet Ben-Barak

  4. Department of Pediatric Radiology, Rambam Health Care Campus, 32 Hatzalbanim str, Haifa, Israel

    Anat Ilivitzki

Authors
  1. Anat Ilivitzki
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  2. Lea Radan
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  3. Miriam Ben-Arush
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  4. Ora Israel
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  5. Ayelet Ben-Barak
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Correspondence to Anat Ilivitzki.

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Ilivitzki, A., Radan, L., Ben-Arush, M. et al. Early interim FDG PET/CT prediction of treatment response and prognosis in pediatric Hodgkin disease—added value of low-dose CT. Pediatr Radiol 43, 86–92 (2013). https://doi.org/10.1007/s00247-012-2517-9

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  • DOI: https://doi.org/10.1007/s00247-012-2517-9

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