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The evaluation of FDG-PET imaging for epileptogenic focus localization in patients with MRI positive and MRI negative temporal lobe epilepsy

  • Diagnostic Neuroradiology
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Abstract

Introduction

We studied the contribution of interictal FDG-PET ([18 F] fluorodeoxyglucose-positron emission tomography) in epileptic focus identification in temporal lobe epilepsy patients with positive, equivocal and negative magnetic resonance imaging (MRI).

Methods

Ninety-eight patients who underwent surgical treatment for drug resistant temporal lobe epilepsy after neuropsychological evaluation, scalp video EEG monitoring, FDG-PET, MRI and/or long-term intracranial EEG and with >12 months clinical follow-up were included in this study. FDG-PET findings were compared to MRI, histopathology, scalp video EEG and long-term intracranial EEG monitoring.

Results

FDG-PET lateralized the seizure focus in 95 % of MRI positive, 69 % of MRI equivocal and 84 % of MRI negative patients. There was no statistically significant difference between the surgical outcomes among the groups with Engel class I and II outcomes achieved in 86 %, 86 %, 84 % of MRI positive, equivocal and negative temporal lobe epilepsy patients, respectively. The patients with positive unilateral FDG-PET demonstrated excellent postsurgical outcomes, with 96 % Engel class I and II. Histopathology revealed focal lesions in 75 % of MRI equivocal, 84 % of MRI positive, and 23 % of MRI negative temporal lobe epilepsy cases.

Conclusion

FDG-PET is an accurate noninvasive method in lateralizing the epileptogenic focus in temporal lobe epilepsy, especially in patients with normal or equivocal MRIs, or non-lateralized EEG monitoring. Very subtle findings in MRI are often associated with histopathological lesions and should be described in MRI reports. The patients with negative or equivocal MRI temporal lobe epilepsy are good surgical candidates with comparable postsurgical outcomes to patients with MRI positive temporal lobe epilepsy.

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Conflict of interest

We declare that we have no conflict of interest.

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Authors and Affiliations

  1. Department of Radiology, Mercy Catholic Medical Center, Drexel University, 1500 Lansdowne, Avenue Darby, Philadelphia, PA, 19023, USA

    Beril Gok & Reza Hayeri

  2. Division of Nuclear Medicine, Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA

    Beril Gok & Richard Wahl

  3. Department of Neurosurgery, Johns Hopkins University, Baltimore, MD, USA

    George Jallo

  4. Division of Neuroradiology, Department of Radiology and Radiological Sciences, Johns Hopkins University, Baltimore, MD, USA

    Nafi Aygun

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  1. Beril Gok
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Correspondence to Beril Gok.

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Gok, B., Jallo, G., Hayeri, R. et al. The evaluation of FDG-PET imaging for epileptogenic focus localization in patients with MRI positive and MRI negative temporal lobe epilepsy. Neuroradiology 55, 541–550 (2013). https://doi.org/10.1007/s00234-012-1121-x

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  • DOI: https://doi.org/10.1007/s00234-012-1121-x

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