Skip to main content

Advertisement

SpringerLink
Log in

Cerebrospinal fluid and plasma disposition of yohimbine and 11-hydroxy-yohimbine in young and older healthy subjects, and Alzheimer's disease patients

  • PHARMACOKINETICS AND DISPOSITION
  • Published:
European Journal of Clinical Pharmacology Aims and scope Submit manuscript

Abstract

Objective: The plasma and cerebrospinal fluid (CSF) disposition of yohimbine (YO) and 11-hydroxy-yohimbine (11-OH-YO), after oral administration of a single dose of YO (0.65 mg · kg−1) were studied in young and older healthy subjects and in patients with Alzheimer's disease (AD).

Results: Plasma disposition of YO displayed large variability; no significant differences among subject groups were observed. In contrast, 11-OH-YO Cmax and AUC were significantly lower in the older normal subjects than in the young normal or AD subjects. A strong positive correlation between CSF and plasma YO concentrations was observed. A weak positive correlation between CSF and plasma concentrations of 11-OH-YO was also observed. CSF to plasma concentration ratios for yohimbine and 11-OH-YO were low (approximately 2%).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Author information

Authors and Affiliations

  1. Laboratoire de Pharmacie Galénique, Biopharmacie et Pharmacie Clinique, Faculté des Sciences Pharmaceutiques et Biologiques, Université de Rennes I, 2 Avenue du Professeur Léon Bernard, F-35043, Rennes Cedex, France Fax: +33-99-33 68 91; e-mail Pascal.Le-Corre@univ-rennes1.fr, , , , , , FR

    P. A. Le Corre, F. Chevanne & R. Le Verge

  2. Seattle Veterans Affairs Medical Center Geriatric Research, Education and Clinical Center and Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, Seattle, Washington, USA, , , , , , US

    E. R. Peskind & M. A. Raskind

Authors
  1. P. A. Le Corre
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. E. R. Peskind
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. F. Chevanne
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. M. A. Raskind
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. R. Le Verge
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Received: 29 September 1995 / Accepted in revised form: 4 March 1996

Rights and permissions

Reprints and permissions

About this article

Cite this article

Corre, P., Peskind, E., Chevanne, F. et al. Cerebrospinal fluid and plasma disposition of yohimbine and 11-hydroxy-yohimbine in young and older healthy subjects, and Alzheimer's disease patients. E J Clin Pharmacol 52, 135–138 (1997). https://doi.org/10.1007/s002280050262

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s002280050262

Search

Navigation