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Hepatocyte growth factor/scatter factor—Met signaling in tumorigenicity and invasion/metastasis

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Abstract

Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular processes, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy.

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Abbreviations

ECM/BM :

Extracellular matrix/basement membrane

HGF/SF :

Hepatocyte growth factor/scatter factor

uPA :

Urokinase-type plasminogen activator

uPAR :

Urokinase-type plasminogen activator receptor

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  1. Michael Jeffers

    Present address: Central Research Division, Pfizer, Inc., Eastern Point Road, CT 06340, Groton, USA

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  1. ABL-Basic Research Program, NCI-Frederick Cancer Research and Development Center, P.O. Box B, 21702, Frederick, MD, USA

    Michael Jeffers, Sing Rong & George F. Vande Woude

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Jeffers, M., Rong, S. & Vande Woude, G.F. Hepatocyte growth factor/scatter factor—Met signaling in tumorigenicity and invasion/metastasis. J Mol Med 74, 505–513 (1996). https://doi.org/10.1007/BF00204976

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  • DOI: https://doi.org/10.1007/BF00204976

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