Abstract
Dynamic positron emission tomography (PET) was performed following an intravenous bolus injection of15O-water for the assessment of regional pancreatic blood flow in 4 normal volunteers and 11 patients with pancreatic cancer. The regional pancreatic blood flow index (PFI) was calculated by the autoradiographic method assuming the time-activity curves of the aorta as an input function. The mean PFI value was 0.514±0,098 in the normal pancreas but it was decreased in pancreatic cancer (0,249±0,076) (p< 0,0l), with a concomitant decrease in the pancreatic region distal to the tumor. On the other hand, in cases with body or tail cancer, the part proximal to the tumor (nontumorous head region) had a similar PFI value (0.554±0.211) to that of normal cases. Thus, a PET study with15O-water permits quantitative assessment of pancreatic blood flow which decreased in both pancreatic cancer and concomitant obstructive pancreatitis distal to the tumor.
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References
Lunderquist R: Angiography in carcinoma of the pancreas.Acta Radiol Suppl 235: 1, 1965
Boijsen E: Selective pancreatic angiography.Br J Radiol 39: 481–487, 1966
Nebesar RA, Pollard JJ: A critical evaluation of selective celiac and superior mesenteric angiography in the diagnosis of pancreatic disease, particularly malignant tumor: Facts and “Artefacts”.Radiology 89: 1017–1027, 1967
Bookstein JJ, Reuter SR, Martel W: Angiographic evaluation of pancreatic carcinoma.Radiology 93: 757–764, 1969
Reuter SR: Superselective pancreatic angiography.Radiology 92: 74–85, 1969
Reuter SR, Redman HC, Bookstein JJ: Differential problems in the angiographic diagnosis of carcinoma of the pancreas.Radiology 96: 93–99, 1970
Huang SC, Carson RE, Phelps ME: Measurement of local blood flow and distribution volume with short-lived isotopes: A general input technique.J Cereb Blood Flow & Metabol 2: 99–108, 1982
Huang SC, Carson RE, Hoffman EJ, et al: Quantative measurement of local cerebral blood flow in humans by positron emission tomography and15O-water.J Cereb Blood Flow & Metabol 3: 141–153, 1983
Saji H, Enoki K, Tokui T, et al: Constant infusion system of15O-labeled water.Radioisotopes 33: 611–616, 1984
Senda M, Tamaki N, Yonekura Y, et al: Performance characteristics of Positologica III, a whole-body positron emission tomograph.J Comput Assist Tomogr 9: 940–946, 1985
Kety SS: The theory and application of the exchange of inert gas at the lung and tissue.Pharmacol Rev 3: 1–41, 1951
Homma T, Malik KU: Effect of secretin and caerulein in canine pancreas: Relation to prostaglandins.Am J Physiol 244: G660–667, 1983
Lefer AM, Spath JA, Jr: Pancreatic hypoperfusion and the production of myocardial depressant factor in hemorrhagic shock.Ann Surg 179: 868–876, 1974
Glazer G, Needham T:133Xenon clearance for repeat assessment of pancreatic blood flow in the anesthetized dog.J Physiol (London) 240: 32–33 p, 1974
Studley JG, Mathie RT, Blumgart LH: Regional pancreatic perfusion. An experimental study in the dog.Acta Chir Scand 152: 373–378, 1986
Chung RS, Safaie-Shirazi S: The effect of secretin on pancreatic blood flow in the awake and anesthetized dog.Proc Exp Biol Med 173: 620–625, 1983
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Kubo, S., Yamamoto, K., Magata, Y. et al. Assessment of pancreatic blood flow with positron emission tomography and oxygen-15 water. Ann Nucl Med 5, 133–138 (1991). https://doi.org/10.1007/BF03164627
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DOI: https://doi.org/10.1007/BF03164627