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Imaging of adenosine A1 receptors in the human brain by positron emission tomography with [11C]MPDX

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Abstract

We report the first clinical PET study using [1-methyl-11C]8-dicyclopropylmethyl-1-methyl-3-propylxanthine ([11C]MPDX) for imaging adenosine A1 receptors in the human brain. The binding of [11C]MPDX evaluated quantitatively as the distribution volume by a graphical analysis was high in the striatum and thalamus, and low in the cerebellum. The distribution pattern of [11C]MPDX was coincident with that of adenosine A1 receptorsin vitro reported previously, and was different from those of blood flow and [18F]FDG. The [11C]MPDX PET has the potential for mapping adenosine A1 receptors in the human brain.

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Authors and Affiliations

  1. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Tokyo, Japan

    Nobuyoshi Fukumitsu, Kenji Ishii, Yuichi Kimura, Keiichi Oda, Toru Sasaki & Kiichi Ishiwata

  2. Department of Radiology, Jikei University School of Medicine, 3-25-8, Nishi-shinbashi, Minato-ku, 105-846, Tokyo, Japan

    Nobuyoshi Fukumitsu & Yutaka Mori

Authors
  1. Nobuyoshi Fukumitsu
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  2. Kenji Ishii
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  3. Yuichi Kimura
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  4. Keiichi Oda
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  5. Toru Sasaki
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  6. Yutaka Mori
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  7. Kiichi Ishiwata
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Correspondence to Nobuyoshi Fukumitsu.

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Fukumitsu, N., Ishii, K., Kimura, Y. et al. Imaging of adenosine A1 receptors in the human brain by positron emission tomography with [11C]MPDX. Ann Nucl Med 17, 511–515 (2003). https://doi.org/10.1007/BF03006445

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  • DOI: https://doi.org/10.1007/BF03006445

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