Abstract
Heart to mediastinum count ratio (H/M) has been commonly utilized as an indicator of myocardial I-123 MIBG uptake. However, normal ranges of H/M were markedly different among various gamma camera systems. The purpose of this study was to clarify whether scatter correction by two-window method standardizes H/M among various gamma camera systems.Methods: Scatter uncorrected and corrected MIBG imaging was acquired in phantom and human studies in combination with low energy high-resolution collimator (LEHR) and medium energy collimator (MEC). For scatter correction, energy window width of 159 keV±10% was applied to main window imaging and 193 keV±9.5% was applied to upper window imaging for scatter correction.Results: In phantom study, a significant difference was observed in uncorrected H/M among three gamma camera systems using LEHR or MEC (2.09±0.06 vs. 2.58±0.03 in GCA 7200 camera, 2.00±0.07 vs. 2.42±0.06 in DS7 camera and 2.16±0.04 vs. 2.67±0.07 in Vertex plus camera). However, there was no significant difference in corrected H/M among the three gamma camera systems, either with LEHR or MEC (2.70±0.07 vs. 2.69±0.07 in GCA 7200 camera, 2.66±0.05 in DS7 camera and 2.66±0.05 vs. 2.61±0.05 in Vertex plus camera). In human study, uncorrected H/M in DS7 camera with LEHC was significantly lower than that in GCA 7200 camera with MEC (1.60±0.37 vs. 1.85±0.54, N=14). In contrast, the difference was insignificant in corrected H/M (2.12±0.59 vs. 2.16±0.68). There was a very excellent correlation in corrected H/M between DS7 and GCA 7200 cameras (r=0.991, p<0.001).Conclusion: This study demonstrated that scatter correction by the two-window method standardizes the H/M in MIBG scintigraphy either with LEHR or MEC. Scatter corrected H/M can be applied to measure a standardized parameter of MIBG uptake in human clinical studies using various gamma camera systems.
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References
Merlet P, Valette H, Dubois RJ, et al. Prognostic value of cardiac metaiodobenzylguanidine imaging in patients with heart failure.J Nucl Med 1992; 33: 471–477.
Nakata T, Miyamoto K, Doi A, et al. Cardiac death prediction and impaired cardiac sympathetic innervation assessed by MIBG in patients with failing and nonfailing heartsJ Nucl Cardiol 1998; 5: 579–590.
Momose M, Kobayashi H, Iguchi N, et al. Comparison of parameters of123I-MIBG scintigraphy for predicting prognosis in patients with dilated cardiomyopathy.Nucl Med Commun 1999; 20: 529–535.
Cohen-Solal A, Esanu Y, Logeart D, et al. Metaiodobenzylguanidine uptake in patients with moderate chronic heart failure: Relation with peak oxygen uptake and prognosis.J Am Coll Cardiol 1999; 33: 759–766.
Takeishi Y, Atsumi H, Fujiwara S, et al. ACE inhibition reduce cardiac iodine123I-MIBG release in heart failure.J Nucl Med 1997; 38: 1085–1089.
Nishimura T, Sugishita T, Sasaki Y. The results of questionnaire on quantitative assessment of123I-metaiodobenzylguanidine myocardial scintigraphy in heart failure.KAKU IGAKU (Jpn J Nucl Med) 1997; 34: 1139–1148.
Shiga K, Inoue T, Yamamoto K, et al. Difference in heart-to-mediastimun activity ratio of MIBG by the location of the ROI and the kind of collimator.Eizou Jyouhou 1996; 28: 1120–1123.
Motomura N, Ichihara T, Takayama T, Aoki S, Kubo H, Takeda K. Practical compensation method of downscattered component due to high energy photon in123I imaging.KAKU IGAKU (Jpn J Nucl Med) 1999; 36: 997–1005.
Baker GA, Lum DJ, Smith EM, et al. Significance of radiocontaminants in I123 for dosimetry and scintillation camera imaging.J Nucl Med 1976; 17: 740–743.
Macey DJ, DeNardo GL, DeNardo SL, et al. Comparison of Low-and Medium-Energy Collimators for SPECT imaging with Iodine-123-labeled Antibodies.J Nucl Med 1986; 27: 1467–1474.
Bloch P, Sanders T. Reduction of effect of scattered photons on a sodium iodine imaging system.J Nucl Med 1972; 25: 67–72.
Ito H, Iida H, Kinoshita T, Hatazawa J, Okudera T, Uemura K. Effects of scatter correction on regional distribution of cerebral blood flow using I-123-IMP and SPECT.Ann Nucl Med 1999; 13: 331–336.
Narita Y, Eberl S, Iida H, et al. Monte Carlo and experimental evaluation of accuracy and noise properties of two scatter correction methods for SPECT.Phys Med Biol 1996; 41: 2481–2496.
Ichihara T, Ogawa K, Motomura N, et al. Compton scatter compensation using the triple-energy window method for single-and dual-isotope SPECT.J Nucl Med 1993; 34: 2216–2221.
Ogawa K. Simulation study of triple-energy-window scatter correction in combined Tl-201, Tc-99m SPECT.Ann Nucl Med 1994; 8: 277–281.
Floyd CE, Jaszczac RJ, Harris CC, et al. Energy and spatial distribution of multiple order Compton scatter in SPECT: a Monte Carlo investigation.Phys Med Biol 1984; 29 385–391.
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Kobayashi, H., Momose, M., Kanaya, S. et al. Scatter correction by two-window method standardizes cardiac I-123 MIBG uptake in various gamma camera systems. Ann Nucl Med 17, 309–313 (2003). https://doi.org/10.1007/BF02988527
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DOI: https://doi.org/10.1007/BF02988527