Abstract
Background: Regional dysfunction demonstrated by Tc-99m-diethylenetriamine-penta-acetic acid-galactosyl human serum albumin (GSA) scintigraphy due to regional decrease in the portal venous flow has previously been reported. In this study, we call attention to the significance of unilateral portal venous flow decrease for preoperative hepatectomy simulation, and evaluate the hepatectomy simulation discrepancy between Tc-99m-GSA single-photon emission computed tomography (SPECT) and CT volumetry.Methods: Twenty-four hepatectomy candidates underwent preoperative hepatectomy simulation by both Tc-99m-GSA SPECT and CT volumetry. Both anatomical and functional resection ratios were calculated by means of CT volumetry and Tc-99m-GSA SPECT, respectively. The differences and ratios between anatomical and functional resection ratios were calculated in all patients, and compared in patients with and without unilateral portal venous flow decrease.Results: Anatomical resection ratios were 28.0±11.7 (mean±standard deviation) in patients with unilateral portal venous flow decrease, and 42.1±15.7 in patients without unilateral portal venous flow decrease (p=0.0127). Functional resection ratios were 14.7±12.8 in patients with unilateral portal venous flow decrease and 40.5±14.6 in patients without (p=0.0004). The differences between anatomical and functional resection ratios were 13.0±7.9 in patients with unilateral portal venous flow decrease and 5.6±3.1 in patients without (p=0.0009). The ratios between anatomical and functional resection ratios were 0.48±0.29 in patients with unilateral portal venous flow decrease and 0.86±0.10 in patients without (p=0.0018). In 12 of the 13 patients with unilateral portal venous flow decrease, anatomical resection ratios were found to be larger than functional resection ratios, whereas this happened in only 6 of 11 patients without unilateral portal venous flow decrease (p=0.0063).Conclusion: Unilateral portal venous flow decrease is suspected to be a major factor in the discreapancy between hepatectomy simulations with radionuclide receptor imaging and CT volumetry.
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References
Kawa S, Tanaka Y. A quantitative model of technetium-99m-DTPA-galactosyl-HSA for the assessment of hepatic binding receptor.J Nucl Med 1991; 32: 2233–2240.
Koizumi K, Uchiyama G, Arai T, Ainoda T, Yoda Y. A new liver functional study using Tc-99m DTPA-galactosyl human serum albumin: evaluation of the validity of several functional parameters.Ann Nucl Med 1992; 6: 83–87.
Akaki S, Mitsumori A, Kanazawa S, Togami I, Takeda Y, Joja I, et al. Technetium-99m-DTPA-galactosyl human serum albumin liver scintigraphy evaluation of regional CT/MRI attenuation/signal intensity differences.J Nucl Med 1998; 39: 529–532.
Akaki S, Kanazawa S, Tsunoda M, Okumura Y, Togami I, Kuroda M, et al. Nontumorous decrease in Tc-99m GSA accumulation.Ann Nucl Med 2000; 14: 477–483.
Akaki S, Mitsumori A, Kanazawa S, Takeda Y, Joja I, Hiraki Y, et al. Reduced radioactivity in the periphery of the liver in a patient with idiopathic portal hypertension.Clin Nucl Med 1997; 22: 369–371.
Akaki S, Okumura Y, Yasui K, Kanazawa S, Togami I, Takeda Y, et al. Three different areas of decreased hepatic radioactivity secondary to a hilar mass.Clin Nucl Med 2001; 26: 243–244.
Akaki S, Mitsumori A, Kanazawa S, Togami I, Takeda Y, Hiraki Y. Lobar decrease in99mTc-GSA accumulation in hilar cholangiocarcinoma.J Nucl Med 1999; 40: 394–398.
Mitsumori A, Nagaya I, Kimoto S, Akaki S, Togami I, Takeda Y, et al. Preoperative evaluation of hepatic functional reserve following hepa-tectomy by technetium-99m galactosyl human serum albumin liver scintigraphy and computed tomography.Eur J Nucl Med 1998; 25: 1377–1382.
Hwang EH, Taki J, Shuke N, Nakajima K, Kinuya S, Konishi S, et al. Preoperative assessment of residual hepatic functional reserve using99mTc-DTPA-galactosyl human serum albumin dynamic SPECT.J Nucl Med 1999; 40: 1644–1651.
Kwon AH, Matsui Y, Kawa S, Kamiyama Y. Functional hepatic volume measured by technetium-99m-galactosyl human serum albumin liver scintigraphy: comparison between hepatocyte volume and liver volume by computed tomography.Am J Gastroenterol 2001; 96: 541–546.
Morimoto T, Honda G, Kawai Y, Hirose T, Nishio T, Shinkura N, et al. Right hepatic lobectomy for hepatocellular carcinoma which developed in primary biliary cirrhosis: report of a case.Surg Today 1999; 29: 646–650.
Sugai Y, Komatani A, Hosoya T, Yamaguchi K. Response to percutaneous transhepatic portal embolization: new proposed parameters by99mTc-GSA SPECT and their usefulness in prognostic estimation after hepatectomy.J Nucl Med 2000; 41: 421–425.
Azoulay D, Castanig D, Smail A, Adam R, Calliez V, Laurent A, et al. Resection of nonresectable liver metastases from colorectal cancer after percutaneous portal vein embolization.Ann Surg 2000; 231: 480–486.
Nakano H, Yoshida K, Takeuchi S, Kumada K, Yamaguchi M, Jaeck D. Liver scintigraphy is useful for selecting candidates for preoperative transarterial chemoembolization among patients with hepatocellular carcinoma and chronic liver disease.Am J Surg 1999; 178: 385–389.
Takeuchi S, Nakano H, Kim YK, Kumada K, Nagasaki H, Sasaki J, et al. Predicting survival and post-operative complications with Tc-GSA liver scintigraphy in hepatocellular carcinoma.Hepato-Gastroenterol 1999; 46: 1855–1861.
Xu JC, Vera DR, Stadalnik RC. Automatic preparation of radiopharmacokinetic data forin vivo estimation of receptor biochemistry.J Nucl Med 1996; 37: 1896–1902.
Kurtaran A, Müller C, Novacek G, Kaserer K, Mentes M, Raderer M, et al. Distinction between hepatic focal nodular hyperplasia and malignant liver lesions using technetium-99m-galactosyl-neoglycoalbumin.J Nucl Med 1997; 38: 1912–1915.
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Akaki, S., Okumura, Y., Sasai, N. et al. Hepatectomy simulation discrepancy between radionuclide receptor imaging and CT volumetry: influence of decreased unilateral portal venous flow. Ann Nucl Med 17, 23–29 (2003). https://doi.org/10.1007/BF02988255
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DOI: https://doi.org/10.1007/BF02988255