Abstract
In patients with cerebral tumors, high accumulations ofl-methyl-11C-methionine (11C-Met) have been reported in some cases of cerebral ischemic disease, but no high accumulations of11C-Met in areas where only transient arterial occlusions are most likely to occur have been reported. Herein we present a case of a high accumulation of11C-Met in an area of frontal interhemispheric cerebral infarction and a moderately high accumulation with an unclear margin in a distant frontal convexity area. A craniotomy revealed a subacute stage of cerebral infarction in the interhemispheric lesion, and an ischemic change in the distant convexity area. Sixteen months after onset, CT scans demonstrated an infarction area in the interhemispheric lesion only, and no atrophic changes were observed in the distant convexity area indicating that no serious tissue damage had occurred.
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Ogawa T, Shishido F, Kanno I, Inugami A, Fujita H, Murakami M, et al. Cerebral glioma: Evaluation with methionine PET.Radiology 1993; 186: 45–53.
Mosskin M, von Holst H, Rergstöm M, Collins VP, Eriksson L, Johnström P, et al. Positron emission tomography with11C-methionine and computed tomography of intracranial tumors compared with histopathologic examination of multiple biopsies.Acta Radiological 1987; 28: 673–681.
Goldman S, Levovoer M, Pirotte B, Brucher JM, Wikler D, Damhaut P, et al. Regional methionine and glucose uptake in high-grade gliomas: a comparative study on PET-guided stereotactic biopsy.J Nucl Med 1997; 38: 1459–1462.
Derlon JM, Petit-Taboue MC, Chapon F, Beaudouin V, Noel MH, Creveuil C, et al. Thein vivo metabolic pattern of low-grade brain gliomas: a positron emission tomographic study using18F-fluorodeoxyglucose and11C-l-methyl methionine.Neurosurgery 1997; 40: 287–288.
Kascheten B, Stevenaert A, Sadzot B, Deprez M, Degieldre C, Del Fiore G, et al. Preoperative evaluation of 54 gliomas by PET with fluorine-18-fluorodeoxyglucose and/or carbon-11-methionine.J Nucl Med 1998; 39: 778–785.
Ericson K, von Holst H, Mosskin M, Bergström M, Lindqvist M, Noren G, et al. Positron emission tomography of cavernous hemangiomas of the brain.Acta Radiologica Diagnosis 1986; 27: 379–383.
Suzuki A, Mineura K, Sasashima T, Kowada M, Ogawa T, Hatazawa J, et al. Sequential analysis of the integrated images of PET, CT and MR in malignant brain tumors before and after radiotherapy.No to Shinkei—Brain & Nerve 1996; 48: 449–457.
Jacobs A. Amino acid uptake in ischemically compromised brain tissue.Stroke 1995; 26: 1859–1866.
Mineura K, Sasajima T, Kowada M, Ogawa T, Hatazawa J, Uemura K. Indications for differential diagnosis of nontumor central nervous system diseases from tumors.J Neuroimaging 1997; 7: 8–15.
Ishii K, Ogawa T, Hatazawa J, Kanno I, Inugami A, Shimosegawa E, et al. Highl-methyl-[11C]methionine uptake in brain abscess: A PET study.J Comput Assist Tomogr 1993; 17: 660–661.
Dethy S, Goldman S, Blecic S, Luxen A, Levivier M, Hildebrand J. Carbon-11-methionine and fluorine-18-FDG PET study in brain hematoma.J Nucl Med 1994; 35: 1162–1166.
Tashima T, Morioka T, Nishio S, Hachisuga S, Fukui M, Sasaki M. Delayed cerebral radionecrosis with high uptake of11C-methionine on positron emission tomography and201Tl-chloride on single-photon emission computed tomography.Neuroradiology 1998; 40: 435–438.
Ochi H, Yamada T, Hara H, Yoshimura T, Iwaki T, Nagashima K, et al. A case of progressive multifocal leukoencephalopathy with methionine uptake demonstrated by PET.Clin Neurol 1996; 36: 858–863.
Okuda B, Kawabata K, Tachibana H, Sugita M. Cerebral blood flow in pure dysarthria: role of frontal cortical hypoperfusion.Stroke 1999; 30: 109–113.
Ishiwata K, Kubota K, Murakami M, Kubota R, Sasaki T, Ishii S, et al. Re-evaluation of amino acid PET studies: Can the protein synthesis rates in brain and tumor tissues be measuredin vivo? J Nucl Med 1993; 34: 1936–1943.
Kubota R, Kubota K, Yamada S, Tada M, Takahashi T, Iwata R, et al. Methionine uptake by tumor tissue: A microautoradiographic comparison with FDG.J Nucl Med 1995; 36: 484–492.
Uemura Y, Kowall NW, Moskowitz MA. Focal ischemia in rats causes time-dependent expression of c-fos protein immunoreactivity in widespread regions of ipsilateral cortex.Brain Research 1991; 552: 99–105.
Kinouchi H, Sharp FR, Chan PH, Koisinaho J, Sagar SM, Yoshimoto T. Induction of c-fos, junB, c-jun, and hsp70 mRNA in cortex, thalamus, basal ganglia, and hippocampus following middle cerebral artery occlusion.J Cereb Blood Flow Metab 1994; 14: 808–817.
Garcia JH, Lassen NA, Weiller C, Sperling B, Nakagawara J. Ischemic stroke and incomplete infarction.Stroke 1996; 27 (4): 761–765.
Lin B, Ginsberg MD, Busto R, Dietrich WD. Sequential analysis of subacute and chronic neuronal, astrocytic and microglial alterations after transient global ischemia in rats.Acta Neuropathol 1998; 95: 511–523.
Kondo Y, Ogawa N, Asanuma M, Ota Z, Mori A. Regional differences in late-onset iron deposition, ferritin, transferrin, astrocyte proliferation, and microglial activation after transient forebrain ischemia in rat brain.J Cered Blood Flow Metab 1995; 14: 216–226.
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Nagano-Saito, A., Kato, T., Wakabayashi, T. et al. High- and moderately high-methionine uptake demonstrated by PET in a patient with a subacute cerebral infarction. Ann Nucl Med 15, 387–391 (2001). https://doi.org/10.1007/BF02988250
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DOI: https://doi.org/10.1007/BF02988250