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Copper-62 ATSM as a hypoxic tissue tracer in myocardial ischemia

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Abstract

Copper-62 labeled diacetyl-bis (N 4-methylthiosemicarbazone) (62Cu-ATSM) has been proposed as a generator produced positron-emitting tracer for hypoxic tissue imaging. To clarify the usefulness of62Cu-ATSM for myocardial ischemia,62Cu-ATSM PET was performed in 7 patients with coronary artery disease. Increased myocardial uptake of62Cu-ATSM was observed (myocardium/blood ratio: 3.09) in one patient with unstable angina, who had increased18F-fluorodeoxyglucose (18F-FDG) uptake under the fasting condition. The other 6 patients, who were clinically stable, did not have increased62Cu-ATSM uptake, although abnormal18F-FDG uptake was seen in 4 patients. This preliminary study suggests that62Cu-ATSM is a promising PET tracer for hypoxic imaging in acute ischemia.

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Authors and Affiliations

  1. Biomedical Imaging Research Center, Fukui Medical University, Shimoaizuki, Matsuokacho, Yoshida-gun, 910-1137, Fukui, Japan

    Yasuhisa Fujibayashi, Yoshiharu Yonekura, Atsuo Waki & Norihiro Sadato

  2. First Department of Internal Medicine, Fukui Medical University, Shimoaizuki, Matsuokacho, Yoshida-gun, 910-1137, Fukui, Japan

    Akira Nakano & Jong-Dae Lee

  3. Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA

    Michael J. Welch

  4. Department of Radiology, Fukui Medical University, Shimoaizuki, Matsuokacho, Yoshida-gun, 910-1137, Fukui, Japan

    Norio Takahashi, Tatsuro Tsuchida, Katsuya Sugimoto & Harumi Itoh

Authors
  1. Norio Takahashi
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  2. Yasuhisa Fujibayashi
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  3. Yoshiharu Yonekura
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  4. Michael J. Welch
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  5. Atsuo Waki
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  6. Tatsuro Tsuchida
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  7. Norihiro Sadato
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  8. Katsuya Sugimoto
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  9. Akira Nakano
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  10. Jong-Dae Lee
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  11. Harumi Itoh
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Corresponding author

Correspondence to Tatsuro Tsuchida.

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Takahashi, N., Fujibayashi, Y., Yonekura, Y. et al. Copper-62 ATSM as a hypoxic tissue tracer in myocardial ischemia. Ann Nucl Med 15, 293–296 (2001). https://doi.org/10.1007/BF02987849

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  • DOI: https://doi.org/10.1007/BF02987849

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