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Use of reference tissue models for quantification of histamine H1 receptors in human brain by using positron emission tomography and [11C]doxepin

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Abstract

The aim of the present study is to evaluate the validity of the simplified reference tissue model (SRTM) and of Logan graphical analysis with reference tissue (LGAR) for quantification of histamine H1 receptors (H1Rs) by using positron emission tomography (PET) with [11C]doxepin. These model-based analytic methods (SRTM and LGAR) are compared to Logan graphical analysis (LGA) and to the one-tissue model (1TM), using complete datasets obtained from 5 healthy volunteers. Since H1R concentration in the cerebellum can be regarded as negligibly small, the cerebellum was selected as the reference tissue in the present study. The comparison of binding potential (BP) values estimated by LGAR and 1TM showed good agreement; on the other hand, SRTM turned out to be unstable concerning parameter estimation in several regions of the brain. By including the results of noise analysis, LGAR became a reliable method for parameter estimation of [11C]doxepin data in the cortical regions.

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Authors and Affiliations

  1. Department of Quantum Science and Energy Engineering, Tohoku University, Aramaki-aza-aoba 01, Sendai 980-8579, Aoba-ku, Japan

    Atsuro Suzuki & Keizo Ishii

  2. Cyclotron and Radioisotope Center, Tohoku University, Japan

    Manabu Tashiro

  3. Positron Medical Center, Tokyo Metropolitan Institute of Gerontology, Japan

    Yuichi Kimura, Kenji Ishii & Kiichi Ishiwata

  4. Department of Pharmacology, Tohoku University School of Medicine, Japan

    Hideki Mochizuki & Kazuhiko Yanai

  5. Department of Investigative Radiology, Research Institute, National Cardiovascular Center, Japan

    Hiroshi Watabe

Authors
  1. Atsuro Suzuki
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  2. Manabu Tashiro
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  3. Yuichi Kimura
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  4. Hideki Mochizuki
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  5. Kenji Ishii
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  6. Hiroshi Watabe
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  7. Kazuhiko Yanai
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  8. Kiichi Ishiwata
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  9. Keizo Ishii
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Correspondence to Atsuro Suzuki.

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Suzuki, A., Tashiro, M., Kimura, Y. et al. Use of reference tissue models for quantification of histamine H1 receptors in human brain by using positron emission tomography and [11C]doxepin. Ann Nucl Med 19, 425–433 (2005). https://doi.org/10.1007/BF02985569

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  • DOI: https://doi.org/10.1007/BF02985569

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