Abstract
The authors’ goal was to show the importance of starting scanning at a uniform time after F-18 fluorodeoxyglucose injection in positron emission tomography (PET) brain study.
Method
Fifteen healthy normal subjects underwent FDG-PET to obtain glucose metabolic images starting 60 min and 70 min after FDG injection, respectively. The two sets of images were compared in a voxel-by-voxel analysis.
Results
In the bilateral posterior cingulate gyrus, parietal and frontal association cortices, the FDG uptakes were larger on the 70 min scan images than on the 60 min scan images; the 60 min scans resembled Alzheimer’s metabolic reduction area. Similarly the FDG uptakes were larger in the pons and vermis on the 60 min scan image than on the 70 min scan image.
Conclusions
Regional FDG uptake is different depending on the time scanning starts after FDG injection, even with a 10 minute difference in start time and different scanning time may lead to misdiagnosis. It is important to standardize the start time of FDG PET after FDG injection in brain PET.
This is a preview of subscription content, log in via an institution to check access.
References
Ishii K, Sakamoto S, Hosaka K, Mori T, Sasaki M.Variation in FDG uptake in different regions in normal human brain as a function of the time (30 and 60 minutes) after injection of FDG.Ann Nucl Med 2002; 16: 299–301.
Sakamoto S, Ishii K, Hosaka K, Mori T, Sasaki M, Mori E. Detectability of hypometabolic regions in mild Alzheimer disease: function of time after the injection of 2-[fluorine 18]-fluoro-2-deoxy-d-glucose.AJNR Am J Neuroradiol 2005; 26: 843–847.
Daube-Witherspoon ME, Matej S, Karp JS, Lewitt RM. Application of the row action maximum likelihood algorithm with spherical basis functions to clinical PET imaging.IEEE Trans Nucl Sci 2001; 48: 24–30.
Minoshima S, Frey KA, Koeppe RA, Foster NL, Kuhl DE. A diagnostic approach in Alzheimer’s disease using three-dimensional stereotactic surface projections of fluorine-18-FDGPET.J Nucl Med 1995; 36: 1238–1248.
Reivich M, Alavi A, Wolf A, Greenberg JH, Fowler J, Christman D, et al. Glucose metabolic rate kinetic model parameter determination in humans: The lumped constants and rate constants for [18F]fluorode-oxyglucose and [11C]deoxyglucose.J Cereb Blood Flow Metab 1985; 5: 179–192.
Sasaki H, Kanno I, Murakami M, Shishido F, Uemura K. Tomographic mapping of kinetic rate constants in the fluorodeoxyglucose model using dynamic positron emission tomography.J Cereb Blood Flow Metab 1986; 6: 447–454.
Minoshima S, Giordani B, Barent S, Frey KA, Foster NL, Kuhl DE. Metabolic reduction in the posterior cingulate cortex in very early Alzheimer’s disease.Ann Neurol 1997; 42: 85–94.
Drzezga A, Lautenschlager N, Siebner H, Riemenschneider M, Willoch F, Minoshima S, et al. Cerebral metabolic changes accompanying conversion of mild cognitive impairment into Alzheimer’s disease: a PET follow-up study.Eur J Nucl Med Mol Imaging 2003; 30: 1104–1113.
Chen WP, Matsunari I, Noda A, Yanase D, Yajima K, Takeda N, et al. Rapid scanning protocol for brain18F-FDG PET: a validation study.J Nucl Med 2005; 46: 1633–1641.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Ishii, K., Higashi, Y., Tabata, M. et al. Necessity of a uniform start for scanning after FDG injection in brain PET study. Ann Nucl Med 20, 329–331 (2006). https://doi.org/10.1007/BF02984652
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02984652