Abstract
Quantification of thallium myocardial studies affords the advantage of objectivity over visual analysis. Moreover, comparison of patient profiles to normal limits gives nonexpert readers a sense of confidence for interpreting these studies. Quantification of the washout rate from planar scintigrams aids in overcoming any lack of contrast. Tomography has excellent contrast resolution and identifies most stress perfusion defects without the need for washout calculations. Moreover, with the use of polar displays such as the Bullseye map, the perfusion defect is better characterized by tomography in terms of its location, shape, and size. The main caveat in the use of tomography is that it is technically demanding. The decision as to which method to use depends largely on the application and on the instrumentation and technical expertise available.
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Trobaugh BB, Wackers FJT, Sokole EB, DeRouen TA, Ritchie JL, Hamilton GW (1978) Thallium-201 myocardial imaging: An interinstitutional study of observer variability. J Nucl Med 19:359–363
Garcia EV, Maddahi J, Berman DS, Waxman A: Space-time quantation of thallium-201 myocardial scintigraphy. J Nucl Med 22:309–317
Meade RC, Bamrah VS, Horgan JD, Reutz P, Konenwelter C, Yeh E-L (1978) Quantitative methods in the evaluation of thallium-201 myocardial perfusion images. J Nucl Med 19:1175–1178
Burow RD, Pond M, Schafer AW, Becker L (1979) “Circumferential profiles”: A new method for computer analysis of thallium-201 myocardial perfusion images. J Nucl Med 20:771–777
Watson DD, Campbell NP, Read EK, Gibson RS, Teates CD, Beller GA (1981) Spatial and temporal quantitation of plane thallium myocardial images. J Nucl Med 22:577–584
Vogel RA, Kirch DL, LeFree MT, Rainwater J, Jensen D, Steele P (1979) Thallium 201 myocardial perfusion scintigraphy: Results of standard and multi-pinhole tomographic techniques. Am J Cardiol 43:787–793
Garcia EV, Van Train K, Maddahi J, Prigent F, Areeda J, Waxman A, Berman DS (1985) Quantification of rotational thallium-201 myocardial tomography J Nucl Med 26:17–26
Folks R, Banks L, Plankey M, Mattern J, Greene R, Brust KD, Graham M, Caputo G (1985) Cardiovascular SPECT. J Nucl Med Tech 13:150–161
DePasquale E, Nody A, DePuey G, Garcia E, Pilcher G, Breddan C, Roubin G, Eisner R, Gober A, Gruentzig A, Berger H (1986) Quantitative rotational thallium-201 tomography for identifying and localizing coronary artery disease (CAD): Bullseye polar map. J Am Coll Cardiol 7:22A
Caldwell J, Williams D, Richie J (1985) Single photon emission computed tomography: validation and application for myocardial perfusion imaging. In New Concepts in Cardiac Imaging. Pohost G, Higgins C, Morganroth J, Ritchie J, Shelbert H (eds) G. K. Hall, Boston, 1985, pp 115–136
Goris ML, Daspit SG, McLaughlin P, Kriss J (1976) Interpolative background subtraction. J Nucl Med 17:744–747
Reiber JHC, Lie SP, Simoons ML, Wijns W, Gerbrands JJ (1982) Computer quantitation of location, extent and type of thallium-201 myocardial perfusion abnormalities. Proc. 1st International Symposium on Medical Imaging and Image Interpretation ISMIII. IEEE Cat. No. CH 1804/4/8x: 123–128
Hoffman EJ, Huang SC, Phelps ME (1979) Quantification in positron emission tomography. 1. Effect of object size. J Comput Assist Tomogr 3:299–308
Galt JR, Garcia EV, Robbins WL (1986) SPECT Quantitation: Dependence of Radionuclide Concentration on Object Size. J Nucl Med 27:1799 (abstract)
Okada RD, Lim YL, Boucher CA, Pohost GM, Chesler DA, Block PC (1985) Clinical, angiographic hemodynamic, perfusional and functional changes after one-vessel left anterior descending coronary angioplasty. Am J Cardiol 55:347–356
Areeda J, Van Train K, Garcia E, Maddahi J, Berman D: Improved analysis of segmental thallium myocardial scintigrams: Quantitation of distribution, washout, and redistribution. In Esser P (ed). Digital Imaging. Soc of Nuc Med. New York, pp 257–267
Wackers FJT, Fetternan RC, Mattera JA, Clements JP (1985) Quantitative Planar Thallium-201 Stress Scintigraphy: A critical evaluation of the method. Seminars in Nucl Med XV:1:46–66
Francisco DA, Collins SM, Go RT, Ehrhardt JC, van Kirk OC, Marcus ML (1982) Tomographic thallium-201 myocardial perfusion scintigrams after maximal coronary artery vasodilation with intravenous dipyridamole. Comparison of qualitative and quantitative approaches. Circulation 66:370–379
Van Train K, Berman D, Garcia E, Berger H, Sand M, Friedman J, Freeman M, Pryzlak M, Ashburn W, Norris S, Green A, Maddahi J (1986) Quantitative analysis of stress distribution and washout of thallium-201 myocardial scintigrams: A multicenter trial validation utilizing standard normal limits. J Nucl Med 27:17–25
Maddahi J, Garcia EV, Berman DS, Swan HJC, Forrester J (1981) Improved nonnvasive assessment of coronary artery disease by quantitative analysis of regional stress myocardial distribution and washout of thallium-201. Circulation 64:024–935
Go RT, Cook SA, MacIntyre WJ, Underwood D, Rincon G, Yiamikas J, Napoli C, Salcedo E (1982) Comparative accuracy of stress and redistribution thallium-201 cardiac single photon emission transaxial tomography and planar imaging in the diagnosis of myocardial ischemia. J Nucl Med 23:P24-P25 (abstract)
Maddahi J, Van Train KF, Wong C, Gurewitz J, Prigent F, Youngkin C, Friedman J, Berman D (1986) Comparison of thallium-201 SPECT and planar imaging for evaluation of coronary artery disease. J Nucl Med 27:999 (abstract)
Tamaki S, Najajima H, Murakam T, Yui Y, Kambara H, Kadota K (1982) Estimations of infarct size by myocardial emission computed tomography with thallium-201 and its relation to creatine kinase-MB release after myocardial infarction in man. Circulation 66:994–1001
Ritchie JL, Williams DL, Harp G, Stratton JL, Caldwell JH (1982) Transaxial tomography with thallium-201 for detecting remote myocardial infarction. Am J Cardiol 50:1236–1241
Tamaki N, Yonekura Y, Kadaa S, Senda M, Minato K, Nohara R, Kamhara H, Kawi C, Torizuka K (1984) Value of quantitative stress thallium-201 emission CT for localization of coronary artery disease: comparison with qualitative analysis. J Nucl Med 25:P61 (abstract)
Borello JA, Clinthorne NH, Rogers WL, Thrall JH, Keyes J (1981) Oblique-angle tomography: A restructuring algorithm for transaxial tomographic data. J Nucl Med 22:471–473
Eisner RL, Gober A, Cerqueira M, Pettigrew R, Malko J, Plankey M, Patterson R, McClees E, DePuey EG, Berger HJ (1985) Quantitative analysis of normal thallium-201 tomographic studies. J Nucl Med 26:P49-P50 (abstract)
Caldwell J, Williams D, Harp G, Stratton J, Ritchie J (1984) Quantitation of size of relative myocardial perfusion defect by single-photon emission computed tomography. Circulation 70:1048–1056
DePuey EG, Roubin G, Cloninger K, King S, Garcia E, Robbins W, Berger H (1986) Correlation of transluminal coronary angioplasty parameters and quantitative thallium-201 tomography. J Nucl Med 27:900 (abstract)
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Garcia, E.V., DePuey, E.G. & DePasquale, E.E. Quantative planar and tomographic thallium-201 myocardial perfusion imaging. Cardiovasc Intervent Radiol 10, 374–383 (1987). https://doi.org/10.1007/BF02577348
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DOI: https://doi.org/10.1007/BF02577348