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Pancreatic venous samplings in infants and children with primary hyperinsulinism

  • Selected Papers From The ESPR Meeting In Montreux, Switzerland, 13–16 April 1988
  • Published:
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Abstract

The authors present 19 cases of hyperinsulinism in children worked up with selective pancreatic venous samplings (PVS). Focal lesions were found in 7, diffuse secretion in 8 and normal insulin levels in 4. In three patients with focal hypersecretion less extensive surgery could be performed and confirmed the presence of focal lesions in two. These preliminary results are encouraging and PVS seems to be a valuable technic for detection of focal lesions in the pancreas of children with hyperinsulinism.

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References

  1. Landau H, Prelman M, Meyer S, Isacsohn M, Krausz M, Mayan H, Lijovetzky G, Schiller M (1982) Persistent neonatal hypoglycemia due to hyperinsulinism: medical aspects. Pediatrics 70: 440

    CAS  PubMed  Google Scholar 

  2. Bougneres PF, Landier F, Garnier P, Job JC, Chaussain JL (1985) Treatment of insulin excess by continuous subcutaneous infusion of somatostatin and glucagon in an infant. J Pediatr 106: 792

    CAS  PubMed  Google Scholar 

  3. Kitson HF, McCrossin RB, Jimenez M, Middleton A, Silink M (1980) Somatostatin treatment of insulin excess due to B cell adenoma in a neonate. J Pediatr 96: 145

    CAS  PubMed  Google Scholar 

  4. Carcassonne M, Delarue A, Letourneau JN (1983) Surgical treatment of organic pancreatic hypoglycemia in the pediatric age. J Pediatr Surg 18: 75

    CAS  PubMed  Google Scholar 

  5. Gough MH (1984) The surgical treatment of hyperinsulinism in infancy and childhood. Br J Surg 71: 75

    CAS  PubMed  Google Scholar 

  6. Schiller M, Krausz M, Meyer S, Lijovetzky G, Landau H (1980) Neonatal hyperinsulinism surgical and pathologic considerations. J Pediatr Surg 15: 16

    CAS  PubMed  Google Scholar 

  7. Langer JC, Filler RM, Wesson DE, Sherwood G, Cutz E (1984) Surgical management of persistent neonatal hypoglycemia due to islet cell dysplasia. J Pediatr Surg 19: 786

    CAS  PubMed  Google Scholar 

  8. Aynsley-Green A, Polack JM, Bloom SR, Gough MH, Keeling J, Ashcrof SJH, Turner RC, Baum JD (1981) Nesidioblastosis of the pancreas: definition of the syndrome and the management of the severe neonatal hyperinsulinaemic hypoglycaemia. Arch Dis Child 56: 496

    CAS  PubMed  Google Scholar 

  9. Heitz PU, Kloppel G, Hacki WH, Polak JM, Everson Pearse AG (1977) Nesidioblastosis: the pathologic basis of persistent hyperinsulinemic hypoglycemia in infants. Diabetes 26: 632

    CAS  PubMed  Google Scholar 

  10. Jaffe R, Hashida Y, Yunis EJ (1980) Pancreatic pathology in hyperinsulinemic hypoglycemia of infancy. Lab Invest 42: 356

    CAS  PubMed  Google Scholar 

  11. Knight J, Garvin PJ, Danis RK, Lewis JE, William VL (1980) Nesidioblastosis in children. Arch Surg 115: 880

    CAS  PubMed  Google Scholar 

  12. Laidlaw GF (1938) Nesidioblastoma, the islet tumor of the pancreas. Am J Pathol 14: 125

    Google Scholar 

  13. Rahier J, Falt K, Muntefering H, Becker K, Gepts W, Falkmer S (1984) The basic structural lesion of persistent neonatal hypoglycaemia with hyperinsulinism: deficiency of pancreatic D cells or hyperactivity of B cells. Diabetologia 26: 282

    Article  CAS  PubMed  Google Scholar 

  14. Yakovac WC, Baker I, Hummeler K (1971) Nesidioblastosis in idiopathic hypoglycemia of infancy. J Pediatr 79: 226

    CAS  PubMed  Google Scholar 

  15. Stringel G, Dalpe-Scott M, Perelman AH, Heick HMC (1985) The occult insulinoma operative localization by quick insulin radioimmunoassay. J Pediatr Surg 20: 734

    CAS  PubMed  Google Scholar 

  16. Cho KJ, Vinik AI, Thompson NW, Shields JJ, Porter DJ, Brady TM, Cada G, Fajans SS (1982) Localization of the source of hyperinsulinism: percutaneous transhepatic portal and pancreatic vein catheterization with hormone assay. AJR 139: 237

    CAS  PubMed  Google Scholar 

  17. Glaser B, Valtysson G, Fajans SS, Vinik AI, Cho K, Thompson N (1981) Gastrointestinal pancreatic hormone concentrations in the portal venous system of nine patients with organic hyperinsulinism. Metabolism 30: 1001

    Article  CAS  PubMed  Google Scholar 

  18. Roche A, Raisonnier A, Gillon-Savouret MC (1983) Pancreatic venous sampling and arteriography in localizing insulinomas: procedure and results in 55 cases. Radiology 145: 621

    Google Scholar 

  19. Keller FS, Niles NR, Rosch J, Dotter CT, Stensel-Poore M (1980) Retrograde pancreatic venography-autopsy study. Radiology 135: 285

    CAS  PubMed  Google Scholar 

  20. Derbyshire DR, Smith G (1984) Sympathoadrenal responses to anaesthesia and surgery. Br J Anaesth 7: 725

    Google Scholar 

  21. Hamberger B, Jarnberg PO (1983) Plasma catecholamines during surgical stress: differences between neurolept and enflurane anaesthesia. Acta Anaesthesiol Scand 27: 307

    CAS  PubMed  Google Scholar 

  22. Malatinsky J, Vigas M, Jurcovicova J, Jezova D, Garayova S, Minaricov M (1986) The patterns of endocrine response to surgical stress during different types of anesthesia and surgery in man. Acta Anaesthesiol Belg 37: 23

    CAS  PubMed  Google Scholar 

  23. Sirgurdsson GH, Lindahl SGE, Norden NE (1984) Catecholamine and endocrine response in children during halothane and enflurane anaesthesia for adenoidectomy. Acta Anaesthesiol Scand 28: 47

    Google Scholar 

  24. Demarquez JL, Vital C, Babin JP, Allain O, Bondomy JM; Sautarel M, Tamon F, Martin C (1977) Adenome Langheransien à révélation néonatale. Arch Fr Pediatr 34: 179

    CAS  PubMed  Google Scholar 

  25. Grant DB, Barbor PRH (1970) Islet cell tumour causing hypoglycemia in a newborn infant. Arch Dis Child 45: 434

    CAS  PubMed  Google Scholar 

  26. Habbick BF, Crain RW, Miller KR (1977) Neonatal hypoglycemia resulting from islet cell adenomatosis. Am J Dis Child 131: 210

    CAS  PubMed  Google Scholar 

  27. Rickham PP (1975) Islet cell tumors in childhood. J Pediatr Surg 10: 83

    CAS  PubMed  Google Scholar 

  28. Kirland J, Ben Menachem Y, Akhtar M, Marshall R, Dudrick S (1978) Islet cell tumor in a neonate diagnosis by selective angiography and histological findings. Pediatrics 61: 780

    Google Scholar 

  29. Telander R, Charbonneau JW, Haymond MW (1986) Intraoperative ultrasonography of the pancreas in children. J Pediatr Surg 21: 262

    Article  CAS  PubMed  Google Scholar 

  30. Gorman B, Charbonneau JW, James EM, Reading CC, Galiber AK, Grant CS, Wantteerden JA, Telander RL, Service FJ (1986) Benign pancreatic insulinoma preoperative and intraoperative sonographic localization. AJR 147: 929

    CAS  PubMed  Google Scholar 

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Brunelle, F., Negre, V., Barth, M.O. et al. Pancreatic venous samplings in infants and children with primary hyperinsulinism. Pediatr Radiol 19, 100–103 (1989). https://doi.org/10.1007/BF02387895

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