Summary
Abnormally large glomeruli are susceptible to hyperfiltration-associated sclerosis. We used an established morphometric method to test the general belief that juxtamedullary glomeruli are larger than those in the outer cortex, in a population with no clinical or pathological evidence of renal disease. Overall, juxtamedullary glomeruli were significantly larger, but this varied according to the amount of global glomerulosclerosis present. Global sclerosis increased with age, particularly in the outer cortex, and the ratio of juxtamedullary to outer cortical glomerular size showed a positive correlation with overall, and outer cortical, global sclerosis. Thus in the truly normal adult kidney, juxtamedullary glomeruli are not significantly larger than outer cortical glomeruli. However, global sclerosis increases with age and is most marked in the outer cortex, and this leads to compensatory enlargement of predominantly the juxtamedullary glomeruli. These findings suggest that in single kidneys, or in conditions characterised by ischaemic glomerulosclerosis such as hypertension, morphological changes related to hyperfiltration may appear first, and therefore become most severe, in juxtamedullary glomeruli.
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Bhathena DB, Julian BA, McMorrow RG, Bachter RW (1985) Focal sclerosis of hypertrophied glomeruli in solitary functioning kidneys of humans. Am J Kidney Dis 5: 226–232
DuBois D, DuBois EF (1916) Clinical calorimetry. Arch Intern Med 17: 863–871
Elias H, Hennig A (1967) Stereology of the human renal glomerulus. In: Weibel ER, Elias H (eds) Quantitative methods in morphology. Springer, Berlin Heidelberg New York, pp 130–166
Fleck C, Braunlich H (1984) Kidney function after unilateral nephrectomy. Exp Pathol 25: 3–18
Fogo A, Hawkins EP, Berry PL, Glick AD, Chiang ML, MacDonell RC, Ichikawa I (1990) Glomerular hypertrophy in minimal change disease predicts subsequent progression to focal glomerular sclerosis. Kidney Int 38: 115–123
Hanberg-Sorensen F (1972) Quantitative studies of the renal corpuscles. 1. Intraglomerular, interglomerular and interfocal variation in the normal kidney. Acta Pathol Microbiol Scand 80: 115–124
Holtenberg NK, Adams DF, Solomon HS, Rashid A, Abrams HL, Merrill JP (1974) Senescence and the renal vasculature in normal man. Circ Res 34: 309–316
Hurley RM, Drummond KN (1974) Glomerular enlargement in primary renal disease. Arch Pathol 97: 389–391
Hutchins GM, Kutchemeshgi AD (1973) Renal glomerular enlargement in chronic passive congestion. Johns Hopkins Med J 132: 292–300
Kaplan C, Pasternack B, Shah H, Gallo G (1975) Age-related incidence of sclerotic glomeruli in human kidneys. Am J Physiol 80: 227–234
Kappel B, Olsen S (1980) Cortical interstitial tissue and sclerosed glomeruli in the normal human kidney, related to age and sex. A quantitative study. Virchows Arch [A] 387: 271–277
Kasiske BL (1987) Relationship between vascular disease and age-associated changes in the human kidney. Kidney Int 31: 1153–1159
Kasiske BL, Umen AJ (1986) The influence of age, sex, race, and body habitus on kidney weight in humans. Arch Pathol Lab Med 110: 55–60
MacKay K, Striker LJ, Stauffer JW, Agodoa LY, Striker GE (1990) Relationship of glomerular hypertrophy and sclerosis: studies in SV40 transgenic mice. Kidney Int 37: 741–748
Malt RA (1969) Compensatory growth of the kidney. N Engl J Med 280: 1446–1459
McLachlan MSF, Guthrie JC, Anderson CK, Fulker MJ (1977) Vascular and glomerular changes in the ageing kidney. J Pathol 121: 65–78
Newbold KM, Howie AJ (1990a) Determinants of glomerular cross-sectional area. J Pathol 162: 329–332
Newbold KM, Howie AJ (1990b) Analysis of the position of segmental lesions in glomeruli in vasculitic-type glomerulonephritis and other disorders. J Pathol 162: 149–155
Newbold KM, Howie AJ, Girling AJ, Kizaki T, Bryan RL, Carey MP (1989) A simple method for assessment of glomerular size and its use in the study of kidneys in acromegaly and compensatory renal enlargement. J Pathol 158: 139–146
Newbold KM, Howie AJ, Koram A, Adu D, Michael J (1990) Assessment of glomerular size in renal biopsies including minimal change nephropathy and single kidneys. J Pathol 160: 255–258
Yoshida Y, Fogo A, Ichikawa I (1989), Glomerular hemodynamic changes vs hypertrophy in experimental glomerular sclerosis. Kidney Int 35: 654–660
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Newbold, K.M., Sandison, A. & Howie, A.J. Comparison of size of juxtamedullary and outer cortical glomeruli in normal adult kidney. Vichows Archiv A Pathol Anat 420, 127–129 (1992). https://doi.org/10.1007/BF02358803
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DOI: https://doi.org/10.1007/BF02358803