Abstract
In 1987, the United Kingdom Children's Cancer Study Group (UKCCSG) set up a multi-centre study to investigate the toxicity of iodine 131 metaiodobenzyl-guanidine (mIBG) in the treatment of resistant neuroblastoma. Since December 1987, 25 children suffering from neuroblastoma have been treated with131I-mIBG at six UK centres. All centres followed standardised physics and clinical protocols to provide consistent toxicity and dosimetry data. These protocols describe the methods employed for both the tracer study using131I-mIBG and the subsequent therapy. Whole-body dosimetry calculations were performed on data from the tracer study. The activity administered for therapy was the amount predicted to deliver a predefined whole-body dose. Estimates of doses delivered to various organs during treatment are given in Table 1.
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References
Corbett R, Fullbrook A, Meller S, Flower MA (1990)123I metaiodobenzylguanidine single photon emission tomography in the assessment of children with neuroblastoma. In: Evans AE, D'Angio GJ, Knudson AG Jr, Seeger RC (eds) Advances in neuroblastoma research 3. Liss, New York (in press)
Evans A, D'Angio G, Randolph IG (1971) A proposed staging for children with neuroblastoma. Cancer 27:374–378
Evans A, D'Angio G, Propert K, Anderson J, Hann H (1987) Prognostic factors in neuroblastoma. Cancer 59:1853–1859
Flower MA, Schlesinger T, Adam I, Massomi AM, Hinton PJ, McCready VR (1989) Radiation dose assessment in radioiodine therapy. Part II: practical implementation using quantitative scanning and PET, with clinical results on thyroid carcinoma. Radiother Onc 15:345–357
Gray BN, Burton MA, Kelleher D, Klemp P, Matz L (1990) Tolerance of the liver to the effects of Yttrium-90 radiation. Int J Rad Onc Biol Phys 18:619–623
Hoefnagel CA, Voûte PA, de Kraker J, Marcuse HR (1987) Radionuclide diagnosis and therapy of neural crest tumours using131I meta-iodobenzylguanidine. J Nucl Med 28:308–314
Hoefnagel CA, de Kraker J, Voûte PA (1988) Radionuclide treatment of neuroblastoma using131I meta-iodobenzylguanidine. In: Sluyser M, Voûte PA (eds) Molecular biology and genetics of childhood cancers: approaches to neuroblastoma. Ellis Horwood, Chichester, pp 107–120
International Workshop in Paediatric Oncology (1987) Proceedings of the IVth International Workshop in Paediatric Oncology held in Rome, September 1986. The role of mIBG in therapy, diagnosis and monitoring of neuroblastoma. Med Paediatr Oncol 15(no 4):157–228
Lashford LS, Moyes J, Ott R, Fielding SL, Babich J, Meller S, Gordon I, Evans K, Kemshead JT (1988) The biodistribution and pharmacokinetics of meta-iodobenzylguanidine in childhood neuroblastoma. Eur J Nucl Med 13:574–577
Loevinger R, Budinger TF, Watson EE (1989) In: Loevinger R, Budinger TF, Watson EE in collaboration with Medical Internal Radiation Dose (MIRD) committee (eds) MIRD primer for absorbed dose calculations. Society of Nuclear Medicine, New York
Moyes JSE, McCready VR, Fullbrook AC (1989) Case studies with abnormal uptake of mIBG. In: Moyes JSE, McCready VR, Fullbrook AC (eds) Neuroblastoma — mIBG in its management and diagnosis. Springer, Berlin Heidelberg New York, pp 63–137
National Council on Radiation Protection and Measurements (1983) Tables of mean dose per cumulated activity. In: Report no 73. Protection in nuclear medicine and ultrasound diagnostic procedures in children, pp 51–56
O'Donoghue JA, Wheldon TE (1989) Dose-rate effects in biologically targetted radiotherapy. Int J Rad Biol 56:745–749
Ott RJ, Batty V, Webb S, Flower MA, Leach MO, Clack R, Marsden PK, McCready VR, Bateman JE, Sharma H, Smith A (1987) Measurement of radiation dose to the thyroid using positron emission tomography. Br J Radiol 60:245–251
Wieland M, Wu JI, Brown LE, Manger TJ, Swanson DP, Beierwaltes WH (1980) Radiolabelled adrenergic neuron-blocking agents: adrenomedullary imaging with131I iodobenzylguanidine. J Nucl Med 21:349–354
Yalow AA (1956) Dosimetry of therapeutic use of internally administered radio-isotopes. In: Hahn PF (ed) Therapeutic use of artificial radioisotopes. Wiley, New York, pp 49–53
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On behalf of the mIBG Targetting Group of the United Kingdom Children's Cancer Study Group (UKCCSG), University of Leicester, Leicester, UK:Members of the mIBG Targetting Group: Christie Hospital, Manchester- P. Nuttall, S. Owens (Physics), H.R. Gattamaneni (Radiotherapy); Cookridge Hospital, Leeds - M. Sheppard, S. Packar (Physics), S. Cartright, R. Taylor (Radiotherapy); Newcastle General Hospital - A. Simpson, P. Bartholomew (Physics), H. Lucraft (Radiotherapy); Medical School, University of Newcastle upon Tyne - A. Pearson (Paediatric Oncology); Royal Hospital for Sick Children, Edinburgh - T. Eden (Paediatric Oncology); Royal Manchester Childrens' Hospital - P. Morris-Jones (Paediatric Oncology); Royal Marsden Hospital, Sutton - R. Ott, M. Rosenbloom (Physics), S. Meller, R. Corbett, R. Pinkerton (Paediatric Oncology); Royal South Hants Hospital, Southampton - V. Hall (Radiotherapy); Royal Victoria Infirmary, Newcastle upon Tyne - A. Craft (Paediatrics); Southampton General Hospital - G. Blake, M. Tristam (Physics), J. Kohler (Paediatric Oncology), V. Lewington (Nuclear Medicine); St Bartholomews Hospital, London - K. Britton, L. Hawkins (Nuclear Medicine), J. Kingston, J. Moyes (Paediatric Oncology), J. Malpas (Oncology), N. Plowman (Radiotherapy); Western General Hospital, Edinburgh - J. Hannan (Physics), M. Merrick (Nuclear Medicine), A. Rodger (Radiotherapy); Western Infirmary, Glasgow - T. Hilditch (Physics), A. Barrett (Radiotherapy), T. Wheldon, J. O'Donoghue (Radiobiology); Amersham International, Bucks-R. Bayly; UKCCSG Offices, Leicester-J. Barnes.
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Fielding, S.L., Flower, M.A., Ackery, D. et al. Dosimetry of iodine 131 metaiodobenzylguanidine for treatment of resistant neuroblastoma: results of a UK study. Eur J Nucl Med 18, 308–316 (1991). https://doi.org/10.1007/BF02285457
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DOI: https://doi.org/10.1007/BF02285457