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Computed tomography and granulocyte scintigraphy in active inflammatory bowel disease

Comparison with endoscopy and operative findings

  • Intestinal Disorders, Inflammatory Bowel Disease, Immunology, and Microbiology
  • Published:
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Abstract

The accuracy of computed tomography (CT) and [99mTc]HMPAO granulocyte scintigraphy (GS) for detection of bowel localization, inflammatory activity, and complications in acute inflammatory bowel disease (IBD) was prospectively studied in 32 patients. Of each bowel segment, findings on CT and GS were scored by one blinded observer. Findings on operation or endoscopy served as the gold standard. In Crohn's disease (CD, 17 patients), CT detected bowel pathology (sensitivity 71%, specificity 98%), abscesses (sensitivity and specificity 100%), and fistulas (sensitivity 80%, specificity 100%). In CD, GS had a sensitivity of 79% and a specificity of 98% for detection of inflammatory activity. The detection of complications with GS was poor. Segmental inflammatory activity correlated with endoscopy-operative findings for CT (r=0.86,P<0.0001) and GS (r=0.86,P<0.0001). In ulcerative colitis (UC, 15 patients), GS predicted proximal extension of bowel involvement better than CT. In CD, CT is superior to GS for localization of both active and fibrostenotic bowel disease, and in detection of abscesses and fistulas. In UC, GS showed proximal extension more accurately than CT.

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Authors and Affiliations

  1. Department of Gastroenterology, Free University Hospital, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    Jeroen J. Kolkman MD, Theo H. M. Falke MD, PhD, Jan C. Roos MD, PhD, Dilaine H. Van Dijk MS, Ilse M. J. Bannink MS, Willem Den Hollander, Miguel A. Cuesta MD, PhD, A. Salvador Peña MD, PhD & Stephan G. M. Meuwissen MD, PhD

  2. Department of Radiology, Free University Hospital, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    Jeroen J. Kolkman MD, Theo H. M. Falke MD, PhD, Jan C. Roos MD, PhD, Dilaine H. Van Dijk MS, Ilse M. J. Bannink MS, Willem Den Hollander, Miguel A. Cuesta MD, PhD, A. Salvador Peña MD, PhD & Stephan G. M. Meuwissen MD, PhD

  3. Departments of Nuclear Medicine, and Surgery, Free University Hospital, De Boelelaan 1117, 1081 HV, Amsterdam, The Netherlands

    Jeroen J. Kolkman MD, Theo H. M. Falke MD, PhD, Jan C. Roos MD, PhD, Dilaine H. Van Dijk MS, Ilse M. J. Bannink MS, Willem Den Hollander, Miguel A. Cuesta MD, PhD, A. Salvador Peña MD, PhD & Stephan G. M. Meuwissen MD, PhD

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  1. Jeroen J. Kolkman MD
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  2. Theo H. M. Falke MD, PhD
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  3. Jan C. Roos MD, PhD
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  4. Dilaine H. Van Dijk MS
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  7. Miguel A. Cuesta MD, PhD
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  8. A. Salvador Peña MD, PhD
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Kolkman, J.J., Falke, T.H.M., Roos, J.C. et al. Computed tomography and granulocyte scintigraphy in active inflammatory bowel disease. Digest Dis Sci 41, 641–650 (1996). https://doi.org/10.1007/BF02213118

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  • DOI: https://doi.org/10.1007/BF02213118

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