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A comparison of tumor-related antigens in male and female breast cancer

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Summary

A retrospective analysis was undertaken in which 15 female and 15 male breast cancers were matched by age, stage, estrogen receptor status, and histologic type. Our protocol compares male and female breast cancers for reactivity with antibodies against tumor-associated antigens known to be present on female breast cancer cells. Formalin-fixed sections of each primary tumor were reacted in the ABC immunoperoxidase assay against antibodies B72.3 and DF.3 and an antibody to theras p21 antigen. Reactivity to B72.3 and DF.3 was similar. However, the ras p21 antigen was expressed to a significantly greater extent in female breast cancers (p = .0008). Thus, although there are similarities in antigenic phenotype of male and female breast cancers, some female breast cancers may have a different pathogenesis as demonstrated by increased amounts of a specific oncogene product.

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Authors and Affiliations

  1. Division of Surgical Oncology, SUNY, Stony Brook, New York, USA

    Joel Lundy

  2. Department of Surgery, Winthrop University Hospital, Mineola, New York, USA

    Joel Lundy, Sylvia Chao & Barbara Kasa

  3. Department of Pathology, Winthrop University Hospital, Mineola, New York, USA

    Yousri Mishriki & Allan Schuss

  4. Division of Medical Oncology, SUNY, Stony Brook, New York, USA

    Michael V. Viola & Sheila Oravez

Authors
  1. Joel Lundy
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  2. Yousri Mishriki
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  3. Michael V. Viola
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  4. Sylvia Chao
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  5. Barbara Kasa
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  6. Sheila Oravez
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  7. Allan Schuss
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Lundy, J., Mishriki, Y., Viola, M.V. et al. A comparison of tumor-related antigens in male and female breast cancer. Breast Cancer Res Tr 7, 91–96 (1986). https://doi.org/10.1007/BF01806793

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