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Potential use of iodine-123 metaiodobenzylguanidine radioaerosol as a marker of pulmonary neuroadrenergic function

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Abstract

Iodine-123 metaiodobenzylguanidine (123IMIBG) radioaerosol is of potential use in the investigation of the neuroadrenergic function of the lungs; however, before the method can be successfully employed the following issues need to be clarified: (1) Does the nebulization affect the radiochemical purity of123IMIBG? (2) Is the pulmonary distribution of inhaled123IMIBG homogeneous in normal subjects? (3) Does the pulmonary clearance of inhaled123I-MIBG reflect the functional status of the neuroadrenergic system of the lungs? In this study we performed: (1) a chromatographic study of nebulized123I-MIBG; (2) a quantitative evaluation of the lung distribution of123I-MIBG radioaerosol in normal subjects as compared with that of technetium-99m diethylene triamine penta-acetic acid (99mTc-DTPA) and (3) an assessment of123I-MIBG lung clearance both under control conditions and after pharmacologically induced beta-blockade, again compared with99mTc-DTPA. For these purposes, eight normal subjects were divided randomly into an “MIBG group” and a “DTPA group” (four subjects each) and submitted to three scintigraphic studies each: a baseline study, and studies after the administration of a low (80 mg) and a high (160 mg) dose of propranolol. Radiochemical purity of nebulized123IMIBG ranged between 97.18% and 98.70%. The lung distribution of123I-MIBG, as judged by the aerosol penetration index, was identical to that of99mTc-DTPA under all study conditions. The123I-MIBG clearance rate was slower than that of99mTc-DTPA under baseline conditions (135±32 min vs 69±27 min,P<0.01) and increased significantly after propranolol administrations, while the99mTc-DTPA clearance did not change. The following conclusions were drawn: (1) the nebulization does not affect the radiochemical purity of123I-MIBG; (2) the lung distribution of123I-MIBG is homogeneous in normal subjects; (3) the pulmonary clearance of123IMIBG reflects the functional status of the neuroadrenergic system of the lungs. Thus this scintigraphic method is suitable for research and perhaps for future clinical use.

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Authors and Affiliations

  1. Department of Nuclear Medicine, Catholic University of the Sacred Heart, Rome, Italy

    Alessandro Giordano, Maria Lucia Calcagni, Brunella Rossi & Luigi Troncone

  2. Department of Respiratory Physiology, Catholic University of the Sacred Heart, Rome, Italy

    Leonello Fuso, Daniela Accardo, Salvatore Valente & Riccardo Pistelli

  3. Sorin Biomedica, Saluggia, Italy

    Rodolfo Franceschini

Authors
  1. Alessandro Giordano
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  2. Maria Lucia Calcagni
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  3. Brunella Rossi
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  4. Leonello Fuso
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  5. Daniela Accardo
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  8. Rodolfo Franceschini
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  9. Luigi Troncone
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Giordano, A., Calcagni, M.L., Rossi, B. et al. Potential use of iodine-123 metaiodobenzylguanidine radioaerosol as a marker of pulmonary neuroadrenergic function. Eur J Nucl Med 24, 52–58 (1997). https://doi.org/10.1007/BF01728309

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  • DOI: https://doi.org/10.1007/BF01728309

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