Summary
The recent availability of isotope-labelled somatostatin analogues has allowed one to detect somatostatin receptors in normal tissue as well as in endocrine or non-endocrine cranial tumours. The purpose of the present study was to establish the value of somatostatin receptor scintigraphy using an111Indium-labelled somatostatin analogue, octreotide, in the diagnostic work-up of meningioma patients.
Twenty-two patients (16 women, 6 men, aged from 19–70 years) with newly diagnosed, residual or recurrent cranial meningiomas were examined.111Indium-labelled DTPA-octreotide was injected i.V., Planar and tomographic images were obtained with a gamma camera 4–6, and 24 hours after injection. In all of the meningiomas studied a high density of somatostatin receptors was detected by scintigraphy. No false negative test result was found. Due to this, a 100% predictive value of a negative test was calculated. However, when the tumours were taken in culture differing staining intensity could be seen in the light- and electron microscopic level even on individual cells of a single culture when silver intensified somatostatin-gold was used as ligand.
We conclude, that in vivo somatostatin receptor scintigraphy may aid in the pre-operative differential diagnosis of skull base tumours.
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Supported by the Deutsche Forschungsgemeinschaft (Grant Kr 569-516).
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Hildebrandt, G., Scheidhauer, K., Luyken, C. et al. High sensitivity of the in vivo detection of somatostatin receptors by111Indium (DTPA-octreotide)-scintigraphy in meningioma patients. Acta neurochir 126, 63–71 (1994). https://doi.org/10.1007/BF01476412
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DOI: https://doi.org/10.1007/BF01476412