Skip to main content
SpringerLink
Log in

Somatostatin receptor scintigraphy in patients with pituitary adenoma

  • Published:
Neurosurgical Review Aims and scope Submit manuscript

Abstract

Presence of high-affinity somatostatin (SST) receptors in most endocrine tumor cells allowin vivo scintigraphic visualization of these neoplasms after intravenous administration of a radionuclide-labeled somatostatin analog.n1In-octreotide is at present the most often used substance for imaging of the SST receptor expressionin vivo.

The aim of this study is to investigate the correlation between presence ofin vivo scintigraphically detectable SST receptors in pituitary tumors and clinical parameters such as patients' age, tumor size, hormonal hypersecretion, and response to octreotide therapy. Forty-two consecutive patients were enrolled in this trial. Twenty-five of them had nonsecreting pituitary tumors, 11 were acromegalic, and 6 had macro- or microprolactinoma. Scintigraphic images of the head were obtained at 10 min and 24 hours after injection of the radionuclide. In 23 patients, no specific binding of111In-octreotide was found. Five patients showed a weak positive, 5 had a positive, and 9 a strong positive signal in the region of interest. Uptake of octreotide was significantly correlated with tumor size and age (p < 0.01). Small-size pituitary adenomas were most likely to be scintigraphically receptor-negative, while large suprasellar tumors tended to exhibit a rather strong receptor positivity. Statistical analysis of the data could not confirm the hypothesized correlation between endocrine activity of the pituitary tumors and the scintigraphically proven SST receptor expressionin vivo. A positive Octreoscan was not predictive for the result of octreotide therapy.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Arnberg H, JE Westlin, S Husin, S Nilsson: Distribution and elimination of the somatostatin analogue (111In-DTPA-D-Phel)-octreotide (OctreoScan111). Acta Oncol 32 (1993) 177–182

    PubMed  Google Scholar 

  2. Bakker WH, EP Krenning, WA Breeman, PP Kooij, JC Reubi, JW Koper, M de Jong, JS Lameris, TJ Visser, SW Lamberts: In vivo use of a radioiodinated somatostatin analogue: dynamics, metabolism, and binding to somatostatin receptor-positive tumors in man. J Nucl Med 32 (1991) 1184–1189

    PubMed  Google Scholar 

  3. Bakker WH, EP Krenning, JC Reubi, WA Breeman, B Setyono Han, M de Jong, PP Kooij, C Bruns, PM Van Hagen, P Marbach, et al: In vivo application of [111In-DTPA-D-Phel]-octreotide for detection of somatostatin receptor-positive tumors in rats. Life Sci 49 (1991) 1593–1601

    PubMed  Google Scholar 

  4. Barkan AL, RV Lloyd, WF Chandler: Preoperative treatment of acromegaly with long-acting somatostatin analog SMS 201–205: shrinkage of invasive pituitary macroadenomas and improved surgical remission rate. J. Clin Endocrinol Metab 67 (1988) 1040–1048

    PubMed  Google Scholar 

  5. Bruin TWA de, DJ Kwekkeboom, JW Van't Verlaat, JC Reubi, EP Krenning, SWJ Lamberts, RJM Croughs: Clinically nonfunctioning pituitary adenoma and octreotide response to long term high dose treatment, and studies in vitro. J Clin Endocrinol Metab 75 (1992) 1310–1317

    PubMed  Google Scholar 

  6. Buscail L, N Delesque, JP Esteve, N Saint Laurent, H Prats, P Clerc, P Robberecht, GI Bell, C Liebow, AV Schally, et al.: Stimulation of tyrosine phosphatase and inhibition of cell proliferation by somatostatin analogues: mediationb by human somatostatin receptor subtypes SSTR1 and SSTR2. Proc Natl. Acad Sci USA 91 (1994) 2315–2319

    PubMed  Google Scholar 

  7. Comi RJ, P Gorden: The response of serum growth hormone levels to the longacting somatostatin analog SMS 201-995 in acromegaly. J Clin Endocrinol Metab 64 (1987) 37–42

    PubMed  Google Scholar 

  8. Deherder WW, EP Krenning, CD Malchoff, LJ Hofland, JC Reubi, DJ Kwekkeboom, HY Oei, HAP Pols, HA Bruining, FRE Nobels et al.: Somatostatin receptor scintigraphy — its value in tumor localization in patients with Cushing's syndrome caused by ectopic corticotropin or corticotropin-releasing hormone secretion. Am J Med 96 (1994) 305–312

    PubMed  Google Scholar 

  9. Dorr U, K Wurm, E Horing, G Guzman, U Rath, H Bihl: Diagnostic reliability of somatostatin receptor scintigraphy during continuous treatment with different somatostatin analogs. Horm Metab Res Supp. 27 (1993) 36–43

    Google Scholar 

  10. Duet M, O Mundler, C Ajzenberg, B Berolatti, P Chedin, L Duranteau, A Warnet: Somatostatin receptor imaging in non-functioning pituitary adenomas: Value of an uptake index. Eur J Nucl Med 21 (1994) 647–650

    PubMed  Google Scholar 

  11. Epelbaum J, F Agid, Y Agid, A Beaudet, P Bertrand, A Enjalbert, V Heidet, C Kordon, S Krantic, JF Leonard, et al.: Somatostatin receptors in brain and pituitary. Horm Res 31 (1989) 45–50

    PubMed  Google Scholar 

  12. Faglia G, N Bazzoni, A Spada, M Arosio, B Ambrosi, F Spinelli, R Sara, C Bonino, F Lunghi: In vivo detection of somatostatin receptors in patients with functionless pituitary adenomas by means of a radioiodinated analog of somatostatin ([123I]SDZ 204-090). J Clin Endocrinol Metab 73 (1991) 850–856

    PubMed  Google Scholar 

  13. Ikuyama S, H Nawata, KI Kato, H Ibayashi, H Nagagaki: Plasma growth hormone responses to somatostatin (SRIH) and SRIH receptors in pituitary adenomas in acromegalic patients. J Clin Endocrinol Metab 62 (1986) 729–733

    PubMed  Google Scholar 

  14. Krenning EP, WH Bakker, WA Breeman, JW Koper, PP Kooij, L Ausema, JS Lameris, JC Reubi, SW Lamberts: Localisation of endocrinerelated tumours with radioiodinated analogue of somatostatin. Lancet 1 (1989) 242–244

    PubMed  Google Scholar 

  15. Krenning EP, WH Bakker, PP Kooij, WA Breeman, HY Oei, M de Jong, JC Reubi, TJ Visser, C Bruns, DJ Kwekkeboom, et al.: Somatostatin receptor scintigraphy with indium-111-DTPA-D-Phe-1-octreotide in man: metabolism, dosimetry and comparison with iodine123-Tyr-3-octreotide. J Nucl Med 33 (1992) 652–658

    PubMed  Google Scholar 

  16. Kubota A, Y Yamada, S Kagimoto, A Shimatsu, M Imamura, K Tsuda, H Imura, S Seino, Y Seino: Identification of somatostatin receptor subtypes and an impli cation for the efficacy of somatostatin analogue SMS 201–995 in treatment of human endocrine tumors. J Clin Invest 93 (1994) 1321–1325

    PubMed  Google Scholar 

  17. Lamberts SWJ, WH Bakker, JC Reubi, EP Krenning: Treatment with Sandostatin and in vivo localization of tumors with radiolabeled somatostatin analogs. Metabolism 39 (1990) 152–155

    PubMed  Google Scholar 

  18. Lamberts SWJ, LH Hofland, WW de Herder, DJ Kwekkeboom, JC Reubi, EP Krenning: Octreotide and related somatostatin analogs in the diagnosis and treatment of pituitary disease and somatostatin receptor scintigraphy. Front Neuroendocrinol 14 (1993) 27–55

    PubMed  Google Scholar 

  19. Lamberts SWJ, JC Reubi, WH Bakker, EP Krenning: Somatostatin receptor imaging with123I-Tyr3-Octreotide. Z Gastroenterol 28 (1990) 20–21 (Suppl 2)

    PubMed  Google Scholar 

  20. Lamberts SWJ, M Zweens, JGM Klijn, CCJ van Vroonhoven, SZ Stefanko, E del Pozo: The sensitivity of growth hormone and prolactin secretion to the somatostatin analogue SMS 201–995 in patients with prolactinomas and acromegaly. Clin Endocrinol 25 (1986) 201–212

    Google Scholar 

  21. Landolt AM, H Minder, V Osterwalder, R Jantzer, G Stuckmann: Preoperative treatment of acromegaly with SMS 201–995; surgical and pathological observations. Neuroendocrinol Lett 7 (1985) 94–99

    Google Scholar 

  22. Maini CL, A Tofani, R Sciuto, C Carapella, R Cioffi, M Crecco: Somatostatin receptors in meningiomas: a scimigraphic study using123In-DTPA-D-Phe-1-octreotide. Nucl Med Commun 14 (1993) 550–558

    PubMed  Google Scholar 

  23. Moyse E, M Le Dafniet, J Epelbaum, P Pagesy, F Peillon, C Kordon, A Enjalbert: Somatostatin receptors in human growth hormone and prolactin-secreting pituitary adenomas. J Clin Endocrinol Metab 61 (1985) 98–103

    PubMed  Google Scholar 

  24. Plockinger U, M Reichel, U Fett, W Saeger, HJ Quabbe: Preoperative octreotide treatment of growth hormone-secreting and clinically nonfunctioning pituitary macroadenomas: effect on tumor volume and lack of correlation with immunohistochemistry and somatostatin receptor scintigraphy. J Clin Endocrinol Metab 79 (1994) 1416–1423

    PubMed  Google Scholar 

  25. Raynor K, T Reisine: Subtypes of somatostatin receptors are expressed in the anterior pituitary cell line GH3. J Pharmacol Exp Ther 264 (1993) 110–116

    PubMed  Google Scholar 

  26. Renner U, J Mojto, M Lange, OA Muller, K Vonwerder, GK Stalla: Effect of Bromocriptine and SMS 201–995 on growth of human somatotrophic and non-functioning pituitary adenoma cells in vitro. Eur J Endocrinol 30 (1994) 80–91

    Google Scholar 

  27. Reubi JC, PU Herrz, AM Landolt: Visualization of somatostatin receptors and correlation with immunoreactive growth hormone and prolactin in human pituitary adenomas: evidence for different tumor subclasses. J Clin Endocrinol Metab 65 (1987) 56–73

    Google Scholar 

  28. Reubi JC, E Krenning, SWJ Lamberts, L Kvols: Somatostatin receptors in malignant tissues. J Steroid Biochem Mol Biol 37 (1990) 1073–1077

    PubMed  Google Scholar 

  29. Reubi JC, AM Landolt: The growth hormone responses to octreotide in acromegaly correlate with adenoma somatostatin receptors status. J Clin Endocrinol Metab 68 (1989) 844–850

    PubMed  Google Scholar 

  30. Reubi JC, W Lang, R Maurer, JW Koper, SW Lamberts: Distribution and biochemical characterization of somaytostatin receptors in tumors of the human central nervous system. Cancer Res 47 (1987) 5758–5764

    PubMed  Google Scholar 

  31. Reubi JC, JC Schaer, B Waser, G Mengod: Expression and localization of somatostatin receptor SSTR1, SSTR2, and SSTR3 messenger RNAs in primary human tumors using in situ hybridization. Cancer Res 54 (1994) 3455–3459

    PubMed  Google Scholar 

  32. Scheidhauer K, G Hildebrandt, C Luyken, K Schomacker, N Klug, H Schicha: Somatostatin receptor scintigraphy in brain tumors and pituitary tumors: first experiences. Horm Metab Res Suppl 27 (1993) 59–62

    PubMed  Google Scholar 

  33. Ur E, SJ Mather, J Bomanji, D Ellison, KE Britton, AB Grossman, JA Wass, GM Besser: Pituitary imaging using a labelled somatostatin analogue in acromegaly. Clin Endocrinol 36 (1992) 147–150

    Google Scholar 

  34. Warnet A, J Timsit, P Chanson: The effect of somatostatin analogue on chiasmal dysfunction from pituitary macroadenomas. J Neurosurg 71 (1989) 687–690

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Neurosurgery, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Halle, Germany

    Andreas Rieger, Heike Meyer & Winfried Burkert

  2. Department of Neurosurgery, Justus-Liebig-University Gießen, Germany

    Nikolai G. Rainov M.D. & Christiane Elfrich

  3. Department of Nuclear Medicine, Faculty of Medicine, Martin-Luther-University Halle-Wittenberg, Germany

    Monika Klaua & Traute Mende

  4. Institute for Biostatistics and Medical Informatics, Martin-Luther-University Halle-Wittenberg, Germany

    Christine Lautenschläger

  5. Department of Neurosurgery, Martin-Luther-University Halle Wittenberg, Magdeburger Str.16, D-06097, Halle/Saale, Germany

    Nikolai G. Rainov M.D.

Authors
  1. Andreas Rieger
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Nikolai G. Rainov M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Christiane Elfrich
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Monika Klaua
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Heike Meyer
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Christine Lautenschläger
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Winfried Burkert
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Traute Mende
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rieger, A., Rainov, N.G., Elfrich, C. et al. Somatostatin receptor scintigraphy in patients with pituitary adenoma. Neurosurg. Rev. 20, 7–12 (1997). https://doi.org/10.1007/BF01390518

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01390518

Keywords

Search

Navigation