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Expression of multidrug-resistance-associated protein gene in human soft-tissue sarcomas

  • Original Paper
  • Experimental Oncology
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Abstract

We examined the mRNA expression of the multidrug-resistance-associated protein gene (MRP) in soft-tissue sarcomas and compared it with the expression of the multidrug resistance gene (MDR1), using the reverse transcriptase/polymerase chain reaction. We investigated 39 samples from 33 cases of soft-tissue sarcomas (11 liposarcomas, 9 malignant fibrous histiocytomas, 6 leiomyosarcomas, 4 malignant schwannomas, 3 fibrosarcomas, 3 synovial sarcomas, and 3 epithelioid sarcomas) and 7 benign softtissue tumors. All samples were obtained prior to chemotherapy. An expression ofMRP mRNA was noted in 56% of soft-tissue sarcoma specimens. The co-expression ofMRP andMDR1 was recognized in 15 samples (38%) (5/11 liposarcomas, 5/9 malignant fibrous histiocytomas, 3/6 leiomyosarcomas, 2/3 fibrosarcomas) and significantly correlated with histological grade (P=0.0165). A positive and significant correlation was found betweenMRP andMDR1 expression in soft-tissue sarcomas (P=0.0013). In benign soft-tissue tumors, 1 chemodectoma and 1 neurothekeoma showed lowMRP expression; however, no case showed co-expression ofMRP andMDR1.

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Authors and Affiliations

  1. Institute of Pathology, Faculty of Medicine, Otto-von-Guericke University, Leipziger Str. 44, 39120, Magdeburg, Germany

    Yoshinao Oda, Regine Schneider-Stock & Albert Roessner

  2. Department of Tumor Pathology, Institute of Oncology, Cracow, Poland

    Janusz Ryś, Andrzej Gruchala & Aleksander Niezabitowski

Authors
  1. Yoshinao Oda
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  2. Regine Schneider-Stock
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  3. Janusz Ryś
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  4. Andrzej Gruchala
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  5. Aleksander Niezabitowski
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  6. Albert Roessner
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Oda, Y., Schneider-Stock, R., Ryś, J. et al. Expression of multidrug-resistance-associated protein gene in human soft-tissue sarcomas. J Cancer Res Clin Oncol 122, 161–165 (1996). https://doi.org/10.1007/BF01366956

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  • DOI: https://doi.org/10.1007/BF01366956

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