Abstract
A short-term evaluation of global skeletal uptake (GSU) of technetium-99m methylene diphosphonate (MDP) was performed in 40 healthy female subjects with a wide age range in order to investigate the clinical performance of the technique and to detect the age-related changes in bone turnover. The results obtained were compared with measurements of the main biochemical markers of skeletal metabolism. We found that GSU increases progressively with age, independently of concomitant changes in renal function; significant correlations with biochemical markers of bone formation were also found. Therefore, the method appears to provide useful information concerning the bone turnover rate, and is also applicable to elderly people owing to its simplicity.
Similar content being viewed by others
References
Fogelman I, Bessent RG, Turner JG, Citrin DL, Boyle IT, Greig WR. The use of whole-body retention of Tc-99m diphosphonate in the diagnosis of metabolic bone disease.J Nucl Med 1978; 19: 270–275.
Caniggia A, Vattimo A. Kinetics of 99m technetium-tin-methylene-diphosphonate in normal subjects and pathological conditions: a simple index of bone metabolism.Calcif Tissue Irct 1980; 30: 5–13.
D'Addabbo A, Rubini G, Mele M, Lauriero F. A new method for assessing 99Tc-m-MDP bone uptake from a bone scan image: quantitative measurement of radioactivity in global skeletal regions of interest.Nucl Med Commun 1992; 13: 55–60.
Rubini G, Lauriero F, Rubini D, D'Addabbo A. 99-Tc-mMDP global skeletal uptake and markers of bone metabolism in patients with bone diseases.Nucl Med Commun 1993, 14: 567–572.
Sorenson JA. Nuclear medicine tomography: principles. In: Sorenson JA, Phelps ME, eds. Physics in nuclear medicine. New York: Grune & Stratton; 1987: 391–423.
Goans RE, Abrams SA, Vieira NE, Marini JC, Perez MD, Yergey AL. A three-hour measurement to evaluate bone calcium turnover.Bone 1995; 16: 33–38.
Eastell R, Delmas PD, Hodgson SF, Eriksen EF, Mann KG, Riggs BL. Bone formation rate in older normal women: concurrent assessment with bone histomorphometry, calcium kinetics, and biochemical markers.J Clin Endocrinol Metab 1988; 67: 741–748.
Thomsen K, Johansen J. Nilas L, Christiansen C. Whole body retention of99mTc-diphosphonate. Relation to biochemical indices of bone turnover and to total body calcium.Eur J Nucl Med 1987; 13: 32–35.
Galasko CSB. The pathopbysiological basis for skeletal scintigraphy. In: Galasko CSB, Weber DA, eds. Radionuclide scintigraphy in orthopedics. Edinburgh: Churchill Livingstone; 1984; 34–53.
Sahni M, Guenther HL, Fleish H, Collin P, Martin J. Bisphosphonates act on rat bone resorption through the mediation of osteoblasts.J Clin Invest 1993, 91: 2004–2011.
Hyldstrup L, Clemmensen I, Jensen BA, Transbol I. Noninvasive evaluation of bone formation: measurements of serum alkaline phosphatase, whole body retention of diphosphonate and serum osteocalcin in metabolic bone disorders and thyroid disease.Scand J Clin Lab Invest 1988; 48: 611–619.
Garnero P, Shih WJ, Gineyts E, Karpf DB, Delmas PD. Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment.J Clin Endocrinol Metab 1994; 79: 1693–1700.
Kanis JA. Treatment of osteoporosis in elderly women.Am J Med 1995; 98 Suppl 2A: 60S-66S.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Carnevale, V., Frusciante, V., Scillitani, A. et al. Age-related changes in the global skeletal uptake of technetium-99m methylene diphosphonate in healthy women. Eur J Nucl Med 23, 1473–1477 (1996). https://doi.org/10.1007/BF01254471
Received:
Revised:
Issue Date:
DOI: https://doi.org/10.1007/BF01254471