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Effect of transient reduction of cerebral blood flow in normotensive rats on striatal dopamine-release

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Summary

Bilateral Clamping of both Carotid Arteries (BCCA) in normotensive rats is known to cause a transient reduction in cerebral blood flow. Using in vivo transstriatal microdialysis and HPLC/ECD we measured the release of dopamine and DA-metabolites under these oligemic conditions. BCCA caused a substantial stimulation of striatal DA-release (40-fold) and a decrease of the outflow of DA-metabolites. The elevated DA-release returned to baseline levels before the onset of reperfusion. Upon reperfusion, DA-metabolites rose above their initial baseline values. Transstriatal administration of glutamatediethylester (GDEE, 10 mM) attenuated the oligemia-induced DA-release. A sudden reduction of blood flow appears to disrupt the compartmentation of dopamine in striatal dopaminergic nerve endings in a similar but more moderate manner as compared to ischemia.

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Author notes

  1. S. Läer

    Present address: Max-Planck-Institut für Experimentelle Medizin, Göttingen, Federal Republic of Germany

  2. F. Block

    Present address: Department of Neurology, Hufelandstrasse 55, D-W-4300, Essen, Federal Republic of Germany

Authors and Affiliations

  1. Max-Planck-Institut für Experimentelle Medizin, Göttingen, Federal Republic of Germany

    F. Block & K. -H. Sontag

  2. Psychiatrische Universitätsklinik, Göttingen, Federal Republic of Germany

    G. Huether & C. Heim

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  1. S. Läer
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  2. F. Block
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  3. G. Huether
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  4. C. Heim
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  5. K. -H. Sontag
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Läer, S., Block, F., Huether, G. et al. Effect of transient reduction of cerebral blood flow in normotensive rats on striatal dopamine-release. J. Neural Transmission 92, 203–211 (1993). https://doi.org/10.1007/BF01244879

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  • DOI: https://doi.org/10.1007/BF01244879

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