Abstract
The concept of lethal synthesis as suggested by Peters is reviewed in the light of the more recent work in this area. It is suggested that fluorocitrate is a “suicide” substrate for aconitase rather than a competitive inhibitor as originally suggested. The use of these substances to study glialneuronal relationships is considered.
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Special issue dedicated to Dr. Louis Sokoloff.
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Clarke, D.D. Fluoroacetate and fluorocitrate: Mechanism of action. Neurochem Res 16, 1055–1058 (1991). https://doi.org/10.1007/BF00965850
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DOI: https://doi.org/10.1007/BF00965850