Abstract
Various observations on the cerebellar vasoreactivity in crossed cerebellar diaschisis (CCD) have previously been reported. The purpose of this study is to clarify the difference between oxygen-15 H2O positon emission tomographic (PET) and technetium-99m hexamethylpropylene amine oxime (HMPAO) single-photon emission tomograph (SPET) findings in CCD and to evaluate the effect of the absolute values of the cerebellar blood flow as measured by15O-H2O PET on the99mTc-HMPAO SPET findings. The subjects comprised 15 patients with a supratentorial infarct and CCD. The cerebellar blood flow increased by about 40% at 5 and 20 min after acetazolamide i.v. on both the CCD and the non-CCD side, as measured by 150-1120 PET. The percentage differences in cerebellar blood flow between the CCD and the non-CCD side were −22.3%±5.7% in the resting state, −19.6%±6.4% at 5 min after acetazolamide i.v. and 21.5%±6.7% at 20 min after acetazolamide i.v., as measured by15O-H2O PET, while they were −10.6%±5.5% in the resting state and −5.6%±5.1% at 5 min after acetazolamide i.v., as measured by99mTc-HMPAO SPET. After Lassen's linearization correction, the latter two measurements were −16.2%±7.7% and −9.6%±8.9%, respectively. The effect of acetazolamide did not differ between the CCD and the non-CCD side in15O–H2O PET, while a greater response on the CCD side was observed in99mTc-HMPAO SPET, even after Lassen's linearization correction. It is concluded that acetazolamide HMPAO SPET may overestimate the cerebellar vascular response on the CCD side (or underestimate it on the non-CCD side).
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Kuwabara, Y., Ichiya, Y., Sasaki, M. et al. Cerebellar vascular response to acetazolamide in crossed cerebellar diaschisis: a comparison of99mTc-HMPAO single-photon emission tomography with15O-H2O positron emission tomography. Eur J Nucl Med 23, 683–689 (1996). https://doi.org/10.1007/BF00834531
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DOI: https://doi.org/10.1007/BF00834531